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Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

Overview of attention for article published in BMC Genetics, October 2014
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Title
Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population
Published in
BMC Genetics, October 2014
DOI 10.1186/s12863-014-0113-8
Pubmed ID
Authors

Li-Na Liao, Ching-Chu Chen, Fang-Yang Wu, Cheng-Chieh Lin, Jen-Hao Hsiao, Chwen-Tzuei Chang, Sharon LR Kardia, Tsai-Chung Li, Fuu-Jen Tsai

Abstract

BackgroundDiabetic nephropathy (DN) has become one of the most common causes of end-stage renal disease (ESRD) in many countries, such as 44.5% in Taiwan. Previous studies have shown that there is a genetic component to ESRD. Studies attempting to determine which genetic variants are related to DN in Han Chinese are limited.ResultsWe included 574 unrelated type 2 diabetes patients (217 DN cases and 357 controls), who were genotyped using Illumina HumanHap550-Duo BeadChip. In single-SNP association tests, the SNPs rs11647932, rs11645214, and rs6499323 located at 16q22.1 under the additive-effect disease model were significantly associated with an approximately 2-fold increased risk of DN. In haplotype association tests, identified haplotypes located in the chromosome 16q22.1 region (containing ST3GAL2, COG4, SF3B3, and IL34 genes) raised DN risk. The strongest association was found with haplotype rs2288491-rs4985534-rs11645214 (C-C-G) (adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.83-2.03, p =6.25¿×¿10¿7), followed by haplotype rs8052125-rs2288491-rs4985534-rs11645214 (G-C-C-G) (AOR 1.92, 95% CI 1.82-2.02, p =6.56¿×¿10¿7), and haplotype rs2303792-rs8052125-rs2288491-rs4985534-rs11645214 (A-G-C-C-G) (AOR 1.91, 95% CI 1.81-2.01, p =1.15¿×¿10¿6).ConclusionsOur results demonstrate that the novel SNPs and haplotypes located at the 16q22.1 region may involve in the biological pathways of DN in Han Chinese patients with type 2 diabetes. This study can provide new insights into the etiology of DN.

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Student > Ph. D. Student 3 30%
Researcher 1 10%
Professor 1 10%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Agricultural and Biological Sciences 2 20%
Nursing and Health Professions 1 10%
Psychology 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Other 0 0%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2014.
All research outputs
#3,442,307
of 4,461,916 outputs
Outputs from BMC Genetics
#362
of 474 outputs
Outputs of similar age
#93,093
of 125,043 outputs
Outputs of similar age from BMC Genetics
#23
of 33 outputs
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