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The val158met Polymorphism of Human Catechol-O-Methyltransferase (COMT) Affects Anterior Cingulate Cortex Activation in Response to Painful Laser Stimulation

Overview of attention for article published in Molecular Pain, January 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 669)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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1 blog
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3 X users

Citations

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28 Dimensions

Readers on

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70 Mendeley
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1 CiteULike
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Title
The val158met Polymorphism of Human Catechol-O-Methyltransferase (COMT) Affects Anterior Cingulate Cortex Activation in Response to Painful Laser Stimulation
Published in
Molecular Pain, January 2010
DOI 10.1186/1744-8069-6-32
Pubmed ID
Authors

Arian Mobascher, Juergen Brinkmeyer, Holger Thiele, Mohammad R Toliat, Michael Steffens, Tracy Warbrick, Francesco Musso, Hans-Joerg Wittsack, Andreas Saleh, Alfons Schnitzler, Georg Winterer

Abstract

Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional mu-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val158met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT val158met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 4%
United Kingdom 2 3%
Spain 1 1%
Brazil 1 1%
Unknown 63 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 30%
Researcher 14 20%
Student > Master 7 10%
Professor 6 9%
Student > Bachelor 3 4%
Other 9 13%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 23%
Psychology 12 17%
Medicine and Dentistry 11 16%
Neuroscience 10 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 6 9%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2015.
All research outputs
#2,600,227
of 25,371,288 outputs
Outputs from Molecular Pain
#38
of 669 outputs
Outputs of similar age
#12,358
of 172,619 outputs
Outputs of similar age from Molecular Pain
#1
of 30 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,619 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.