Title |
Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-α inhibitors
|
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Published in |
Arthritis Research & Therapy, February 2011
|
DOI | 10.1186/ar3249 |
Pubmed ID | |
Authors |
Regina Rendas-Baum, Gene V Wallenstein, Tamas Koncz, Mark Kosinski, Min Yang, John Bradley, Samuel H Zwillich |
Abstract |
The long-term treatment of rheumatoid arthritis (RA) most often involves a sequence of different therapies. The response to therapy, disease progression and detailed knowledge of the role of different therapies along treatment pathways are key aspects to help physicians identify the best treatment strategy. Thus, understanding the effectiveness of different therapeutic sequences is of particular importance in the evaluation of long-term RA treatment strategies. The objective of this study was to systematically review and quantitatively evaluate the relationship between the clinical response to biologic treatments and the number of previous treatments with tumor necrosis factor α (TNF-α) inhibitors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Japan | 1 | 1% |
Colombia | 1 | 1% |
Unknown | 76 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 28% |
Other | 12 | 15% |
Student > Ph. D. Student | 11 | 14% |
Student > Master | 9 | 11% |
Student > Postgraduate | 5 | 6% |
Other | 10 | 13% |
Unknown | 10 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 46% |
Agricultural and Biological Sciences | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Nursing and Health Professions | 2 | 3% |
Other | 8 | 10% |
Unknown | 14 | 18% |