Title |
Proteomic profiling and functional characterization of early and late shoulder osteoarthritis
|
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Published in |
Arthritis Research & Therapy, November 2013
|
DOI | 10.1186/ar4369 |
Pubmed ID | |
Authors |
John Paul Wanner, Roopashree Subbaiah, Yelenna Skomorovska-Prokvolit, Yousef Shishani, Eric Boilard, Sujatha Mohan, Robert Gillespie, Masaru Miyagi, Reuben Gobezie |
Abstract |
The development of effective treatments for osteoarthritis (OA) has been hampered by a poor understanding of OA at the cellular and molecular levels. Emerging as a disease of the 'whole joint', the importance of the biochemical contribution of various tissues, including synovium, bone and articular cartilage, has become increasingly significant. Bathing the entire joint structure, the proteomic analysis of synovial fluid (SF) from osteoarthritic shoulders offers a valuable 'snapshot' of the biologic environment throughout disease progression. The purpose of this study was to identify differentially expressed proteins in early and late shoulder osteoarthritic SF in comparison to healthy SF. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Korea, Republic of | 1 | 2% |
Spain | 1 | 2% |
Germany | 1 | 2% |
Unknown | 38 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 21% |
Student > Ph. D. Student | 7 | 17% |
Student > Master | 7 | 17% |
Student > Bachelor | 4 | 10% |
Student > Doctoral Student | 2 | 5% |
Other | 8 | 19% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Engineering | 5 | 12% |
Agricultural and Biological Sciences | 3 | 7% |
Immunology and Microbiology | 3 | 7% |
Other | 8 | 19% |
Unknown | 5 | 12% |