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Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits

Overview of attention for article published in BMC Musculoskeletal Disorders, November 2014
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Title
Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits
Published in
BMC Musculoskeletal Disorders, November 2014
DOI 10.1186/1471-2474-15-370
Pubmed ID
Authors

You Lv, Jie-yun Xia, Jing-yang Chen, Hui Zhao, Hai-cui Yan, Han-shi Yang, Qiang Li, Yu-xin Fan, Kai-jin Guo, Xiang-yang Chen

Abstract

Osteoarthritis (OA) is a major health problem in the increasingly elderly population. Therefore, it is crucial to prevent and treat OA at an early stage. The present study investigated whether pamidronate disodium (PAM), a bone-loss inhibitor, can significantly prevent or reverse the progression of early anterior cruciate ligament transection (ACLT)-induced OA. Whether therapeutic intervention is associated with regulation of the expression of osteoprotegerin (OPG), receptor activator of nuclear factor-κB ligand (RANKL), metalloproteinase-9 (MMP-9) or Toll-like receptor-4 (TLR-4) in cartilage and/or subchondral bone was also investigated.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Student > Bachelor 6 19%
Student > Master 5 16%
Student > Postgraduate 3 9%
Other 2 6%
Other 4 13%
Unknown 6 19%
Readers by discipline Count As %
Medicine and Dentistry 9 28%
Nursing and Health Professions 3 9%
Agricultural and Biological Sciences 3 9%
Computer Science 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 4 13%
Unknown 10 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2014.
All research outputs
#17,731,162
of 22,769,322 outputs
Outputs from BMC Musculoskeletal Disorders
#2,890
of 4,037 outputs
Outputs of similar age
#177,194
of 262,797 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#66
of 108 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,037 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,797 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.