Title |
Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits
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Published in |
BMC Musculoskeletal Disorders, November 2014
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DOI | 10.1186/1471-2474-15-370 |
Pubmed ID | |
Authors |
You Lv, Jie-yun Xia, Jing-yang Chen, Hui Zhao, Hai-cui Yan, Han-shi Yang, Qiang Li, Yu-xin Fan, Kai-jin Guo, Xiang-yang Chen |
Abstract |
Osteoarthritis (OA) is a major health problem in the increasingly elderly population. Therefore, it is crucial to prevent and treat OA at an early stage. The present study investigated whether pamidronate disodium (PAM), a bone-loss inhibitor, can significantly prevent or reverse the progression of early anterior cruciate ligament transection (ACLT)-induced OA. Whether therapeutic intervention is associated with regulation of the expression of osteoprotegerin (OPG), receptor activator of nuclear factor-κB ligand (RANKL), metalloproteinase-9 (MMP-9) or Toll-like receptor-4 (TLR-4) in cartilage and/or subchondral bone was also investigated. |
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