Title |
MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma
|
---|---|
Published in |
BMC Cancer, November 2014
|
DOI | 10.1186/1471-2407-14-799 |
Pubmed ID | |
Authors |
Yukihiro Hirata, Noriyuki Murai, Nozomu Yanaihara, Misato Saito, Motoaki Saito, Mitsuyoshi Urashima, Yasuko Murakami, Senya Matsufuji, Aikou Okamoto |
Abstract |
Epithelial ovarian cancer (EOC) is the most common cause of gynecological malignancy-related mortality. Ovarian clear cell carcinoma (CCC) has unique clinical characteristics and behaviors that differ from other histological types of EOC, including a frequent association with endometriosis and a highly chemoresistant nature, resulting in poor prognosis. However, factors underlying its malignant behavior are still poorly understood. Aberrant expression of microRNAs has been shown to be involved in oncogenesis, and microRNA-21 (miR-21) is frequently overexpressed in many types of cancers. The aim of this study was to investigate the role of miR-21 in 17q23-25 amplification associated with CCC oncogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 29% |
Student > Ph. D. Student | 5 | 14% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Other | 2 | 6% |
Other | 4 | 11% |
Unknown | 8 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 29% |
Agricultural and Biological Sciences | 6 | 17% |
Medicine and Dentistry | 6 | 17% |
Engineering | 2 | 6% |
Chemistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 9 | 26% |