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Constitutional mutation in CDKN2A is associated with long term survivorship in multiple myeloma: a case report

Overview of attention for article published in BMC Cancer, November 2017
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Title
Constitutional mutation in CDKN2A is associated with long term survivorship in multiple myeloma: a case report
Published in
BMC Cancer, November 2017
DOI 10.1186/s12885-017-3715-5
Pubmed ID
Authors

Vallari Shah, Kevin D. Boyd, Richard S. Houlston, Martin F. Kaiser

Abstract

Multiple Myeloma is a cancer of plasma cells associated with significantly reduced survival. Long term survivorship from myeloma is very rare and despite advances in its treatment the disease is generally considered incurable. We report a patient diagnosed with myeloma carrying a germline mutation of a tumour suppressor gene who has effectively been cured. A 36-year-old woman was diagnosed with IgG lambda myeloma in 1985. She was treated with melphalan chemotherapy followed by high-dose melphalan and autologous stem cell rescue and since remained in complete remission despite not having received any additional therapy. After eliciting a prior history of multiple primary melanomas and breast cancer, she was tested for and shown to be a carrier for a germline mutation in CDKN2A. This is the second case report of germline mutation of CDKN2A being associated with myeloma. CDKN2A is a stabiliser of p53. Long term survivorship after high dose DNA damaging chemotherapy with melphalan in this patient is compatible with an increased chemo-sensitivity due to impairment of the DNA repair pathway.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Other 4 15%
Student > Bachelor 4 15%
Student > Master 3 11%
Student > Doctoral Student 2 7%
Other 3 11%
Unknown 5 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 30%
Medicine and Dentistry 8 30%
Nursing and Health Professions 4 15%
Agricultural and Biological Sciences 2 7%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2017.
All research outputs
#14,084,031
of 23,007,887 outputs
Outputs from BMC Cancer
#3,242
of 8,359 outputs
Outputs of similar age
#177,019
of 330,783 outputs
Outputs of similar age from BMC Cancer
#50
of 122 outputs
Altmetric has tracked 23,007,887 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,359 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,783 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.