Title |
Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs
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Published in |
BMC Genomics, November 2014
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DOI | 10.1186/1471-2164-15-967 |
Pubmed ID | |
Authors |
Michael Oster, Eduard Muráni, Siriluck Ponsuksili, Richard B D’Eath, Simon P Turner, Gary Evans, Ludger Thölking, Esra Kurt, Ronald Klont, Aline Foury, Pierre Mormède, Klaus Wimmers |
Abstract |
Brain and immune system are linked in a bi-directional manner. To date, it remained largely unknown why immune components become suppressed, enhanced, or remain unaffected in relation to psychosocial stress. Therefore, we mixed unfamiliar pigs with different levels of aggressiveness. We separated castrated male and female pigs into psychosocially high- and low- stressed animals by skin lesions, plasma cortisol level, and creatine kinase activity obtained from agonistic behaviour associated with regrouping. Peripheral blood mononuclear cells (PBMC) were collected post-mortem and differential gene expression was assessed using the Affymetrix platform (n = 16). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Researcher | 5 | 15% |
Student > Bachelor | 3 | 9% |
Student > Master | 2 | 6% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 12% |
Unknown | 10 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Medicine and Dentistry | 3 | 9% |
Psychology | 2 | 6% |
Sports and Recreations | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 33% |