Title |
Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning
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Published in |
Molecular Brain, November 2014
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DOI | 10.1186/s13041-014-0078-6 |
Pubmed ID | |
Authors |
Jun-Hyeok Choi, Pojeong Park, Gi-Chul Baek, Su-Eon Sim, SukJae Joshua Kang, Yeseul Lee, Seo-Hee Ahn, Chae-Seok Lim, Yong-Seok Lee, Graham L Collingridge, Bong-Kiun Kaang |
Abstract |
Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning. |
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Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 21% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 5 | 15% |
Unknown | 10 | 29% |
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Psychology | 5 | 15% |
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Medicine and Dentistry | 2 | 6% |
Other | 1 | 3% |
Unknown | 10 | 29% |