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Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning

Overview of attention for article published in Molecular Brain, November 2014
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Title
Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning
Published in
Molecular Brain, November 2014
DOI 10.1186/s13041-014-0078-6
Pubmed ID
Authors

Jun-Hyeok Choi, Pojeong Park, Gi-Chul Baek, Su-Eon Sim, SukJae Joshua Kang, Yeseul Lee, Seo-Hee Ahn, Chae-Seok Lim, Yong-Seok Lee, Graham L Collingridge, Bong-Kiun Kaang

Abstract

Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Researcher 4 12%
Student > Doctoral Student 3 9%
Student > Master 3 9%
Student > Bachelor 2 6%
Other 5 15%
Unknown 10 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 24%
Neuroscience 6 18%
Psychology 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Medicine and Dentistry 2 6%
Other 1 3%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2014.
All research outputs
#15,309,583
of 22,769,322 outputs
Outputs from Molecular Brain
#671
of 1,106 outputs
Outputs of similar age
#153,147
of 262,797 outputs
Outputs of similar age from Molecular Brain
#10
of 19 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,797 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.