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Attention Score in Context
| Title |
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
|
|---|---|
| Published in |
Molecular Neurodegeneration, August 2013
|
| DOI | 10.1186/1750-1326-8-30 |
| Pubmed ID | |
| Authors |
Desiree M Baron, Laura J Kaushansky, Catherine L Ward, Reddy Ranjith K Sama, Ru-Ju Chian, Kristin J Boggio, Alexandre J C Quaresma, Jeffrey A Nickerson, Daryl A Bosco |
| Abstract |
Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under conditions of induced stress. Since only the mutants, but not the endogenous wild-type FUS, are associated with stress granules under most of the stress conditions reported to date, the relationship between FUS and stress granules represents a mutant-specific phenotype and thus may be of significance in mutant-induced pathogenesis. While the association of mutant-FUS with stress granules is well established, the effect of the mutant protein on stress granules has not been examined. Here we investigated the effect of mutant-FUS on stress granule formation and dynamics under conditions of oxidative stress. We found that expression of mutant-FUS delays the assembly of stress granules. However, once stress granules containing mutant-FUS are formed, they are more dynamic, larger and more abundant compared to stress granules lacking FUS. Once stress is removed, stress granules disassemble more rapidly in cells expressing mutant-FUS. These effects directly correlate with the degree of mutant-FUS cytoplasmic localization, which is induced by mutations in the nuclear localization signal of the protein. We also determine that the RGG domains within FUS play a key role in its association to stress granules. While there has been speculation that arginine methylation within these RGG domains modulates the incorporation of FUS into stress granules, our results demonstrate that this post-translational modification is not involved. Our results indicate that mutant-FUS alters the dynamic properties of stress granules, which is consistent with a gain-of-toxic mechanism for mutant-FUS in stress granule assembly and cellular stress response. |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Bangladesh | 1 | <1% |
| Unknown | 185 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 22% |
| Student > Master | 30 | 16% |
| Student > Bachelor | 24 | 13% |
| Researcher | 24 | 13% |
| Student > Doctoral Student | 9 | 5% |
| Other | 19 | 10% |
| Unknown | 39 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 29% |
| Biochemistry, Genetics and Molecular Biology | 44 | 24% |
| Neuroscience | 24 | 13% |
| Medicine and Dentistry | 10 | 5% |
| Chemistry | 4 | 2% |
| Other | 10 | 5% |
| Unknown | 41 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#4,765,602
of 23,056,273 outputs
Outputs from Molecular Neurodegeneration
#541
of 857 outputs
Outputs of similar age
#42,070
of 200,901 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 8 outputs
Altmetric has tracked 23,056,273 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 857 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.