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Attention Score in Context
| Title |
Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer
|
|---|---|
| Published in |
Journal of Translational Medicine, November 2014
|
| DOI | 10.1186/s12967-014-0304-0 |
| Pubmed ID | |
| Authors |
Jiebai Zhou, Zhihui Min, Ding Zhang, William Wang, Francesco Marincola, Xiangdong Wang |
| Abstract |
BackgroundRegulatory T cells (Tregs) and B cells (Bregs) play an important role in the development of lung cancer. The present study aimed to investigate the phenotype of circulating Tregs and Bregs in patients with lung cancer and explore potential mechanism by which lung cancer cells act on the development of both.MethodsPatients with lung cancer (n¿=¿268) and healthy donors (n¿=¿65) were enrolled in the study. Frequencies of Tregs and Bregs were measured by flow cytometry with antibodies against CD4, CD25, CD127, CD45RA, CD19, CD24, CD27 and IL-10 before and after co-cultures. qRT-PCR was performed to evaluate the mRNA levels of RANTES, MIP-1¿, TGF-ß, IFN-¿ and IL-4.ResultsWe found a lower frequency of Tregs and a higher frequency of Bregs in patients with lung cancer compared to healthy donors. Co-culture of lung cancer cells with peripheral blood mononuclear cells could polarize the lymphocyte phenotype in the similar pattern. Lipopolysaccharide (LPS)-stimulated lung cancer cells significantly modulated regulatory cell number and function in an in vitro model.ConclusionWe provide initial evidence that frequencies of peripheral Tregs decreased or Bregs increased in patients with lung cancer, which may be modulated directly by lung cancer cells. It seems cancer cells per se plays a crucial role in the development of tumor immunity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 18% |
| Student > Master | 10 | 16% |
| Researcher | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 19% |
| Medicine and Dentistry | 10 | 16% |
| Immunology and Microbiology | 9 | 15% |
| Agricultural and Biological Sciences | 6 | 10% |
| Business, Management and Accounting | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 20 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#18,383,471
of 22,770,070 outputs
Outputs from Journal of Translational Medicine
#2,941
of 3,982 outputs
Outputs of similar age
#185,502
of 258,972 outputs
Outputs of similar age from Journal of Translational Medicine
#62
of 92 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,982 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,972 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.