Title |
Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through the induction of heme oxygenase-1
|
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Published in |
BMC Complementary Medicine and Therapies, November 2014
|
DOI | 10.1186/1472-6882-14-442 |
Pubmed ID | |
Authors |
Bing Zhao, Jian Fei, Ying Chen, Yi-Lin Ying, Li Ma, Xiao-Qin Song, Jie Huang, Er-Zhen Chen, En-Qiang Mao |
Abstract |
Vitamin C (VitC) has recently been shown to exert beneficial effects, including protecting organ function and inhibiting inflammation, in various critical care conditions, but the specific mechanism remains unclear. Induction of heme oxygenase (HO)-1, a heat shock protein, has been shown to prevent organ injuries in hemorrhagic shock (HS) but the relationship between VitC and HO-1 are still ill-defined so far. Here we conducted a systemic in vivo study to investigate if VitC promoted HO-1 expression in multiple organs, and then tested if the HO-1 induction property of VitC was related to its organ protection and anti-inflammatory effect. |
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Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
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Unknown | 7 | 30% |