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New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis

Overview of attention for article published in Arthritis Research & Therapy, November 2017
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Title
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
Published in
Arthritis Research & Therapy, November 2017
DOI 10.1186/s13075-017-1454-2
Pubmed ID
Authors

Heng Li, Dan Wang, Yongjian Yuan, Jikang Min

Abstract

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are needed for diagnosing and monitoring the progression of OA during its early stages when therapeutic drugs or biological agents are most likely to be effective. Various proteinases involved in articular cartilage degeneration in pre-OA conditions, which may represent the earliest reversible measurable changes, are considered diagnostic and therapeutic targets for early OA. Of these proteinases, matrix metalloproteinase 13 (MMP-13) has received the most attention, because it is a central node in the cartilage degradation network. In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. Moreover, the various entities mentioned in this review might be useful as early biomarkers and for personalized approaches to disease prevention and treatment by improving the phenotyping of early OA patients.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 184 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 15%
Researcher 24 13%
Student > Master 21 11%
Student > Doctoral Student 17 9%
Student > Bachelor 17 9%
Other 29 16%
Unknown 48 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 21%
Medicine and Dentistry 31 17%
Pharmacology, Toxicology and Pharmaceutical Science 15 8%
Agricultural and Biological Sciences 10 5%
Engineering 8 4%
Other 30 16%
Unknown 52 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2018.
All research outputs
#15,523,434
of 25,382,440 outputs
Outputs from Arthritis Research & Therapy
#2,262
of 3,380 outputs
Outputs of similar age
#183,034
of 339,332 outputs
Outputs of similar age from Arthritis Research & Therapy
#42
of 62 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,332 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.