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Genome-wide landscape of position effects on heterogeneous gene expression in Saccharomyces cerevisiae

Overview of attention for article published in Biotechnology for Biofuels and Bioproducts, July 2017
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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Title
Genome-wide landscape of position effects on heterogeneous gene expression in Saccharomyces cerevisiae
Published in
Biotechnology for Biofuels and Bioproducts, July 2017
DOI 10.1186/s13068-017-0872-3
Pubmed ID
Authors

Xiao-Le Wu, Bing-Zhi Li, Wen-Zheng Zhang, Kai Song, Hao Qi, Jun-biao Dai, Ying-Jin Yuan

Abstract

Integration of heterogeneous genes is widely applied in synthetic biology and metabolic engineering. However, knowledge about the effect of integrative position on gene expression remains limited. We established a genome-wide landscape of position effect on gene expression in Saccharomyces cerevisiae. The expression cassette of red fluorescence protein (RFP) gene was constructed and inserted at 1044 loci, which were scattered uniformly in the yeast genome. Due to the different integrative loci on the genome, the maximum relative intensity of RFP is more than 13-fold over the minimum. Plots of the number of strains to RFP relative intensity showed normal distribution, indicating significant position effect on gene expression in yeast. Furthermore, changing the promoters or reporter genes, as well as carbon sources, revealed little consequences on reporter gene expression, indicating chromosomal location is the major determinant of reporter gene expression. We have examined the position effects to integration genes expression in large number loci around whole genome in S. cerevisiae. The results could guide the design of integration loci for exogenous genes and pathways to maximize their expression in metabolic engineering.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 31%
Researcher 13 15%
Student > Master 8 9%
Student > Bachelor 6 7%
Other 5 6%
Other 11 13%
Unknown 18 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 34%
Agricultural and Biological Sciences 21 24%
Chemical Engineering 4 5%
Unspecified 2 2%
Immunology and Microbiology 2 2%
Other 8 9%
Unknown 21 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2021.
All research outputs
#7,962,193
of 25,382,440 outputs
Outputs from Biotechnology for Biofuels and Bioproducts
#537
of 1,578 outputs
Outputs of similar age
#116,760
of 325,319 outputs
Outputs of similar age from Biotechnology for Biofuels and Bioproducts
#18
of 45 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,578 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,319 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.