Title |
Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus
|
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Published in |
BMC Genomics, November 2014
|
DOI | 10.1186/1471-2164-15-975 |
Pubmed ID | |
Authors |
William J Gammerdinger, Matthew A Conte, Enoch A Acquah, Reade B Roberts, Thomas D Kocher |
Abstract |
Sex-determination genes drive the evolution of adjacent chromosomal regions. Sexually antagonistic selection favors the accumulation of inversions that reduce recombination in regions adjacent to the sex-determination gene. Once established, the clonal inheritance of sex-linked inversions leads to the accumulation of deleterious alleles, repetitive elements and a gradual decay of sex-linked genes. This in turn creates selective pressures for the evolution of mechanisms that compensate for the unequal dosage of gene expression. Here we use whole genome sequencing to characterize the structure of a young sex chromosome and quantify sex-specific gene expression in the developing gonad. |
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