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Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study

Overview of attention for article published in Nutrition Journal, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 1,523)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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59 news outlets
blogs
1 blog
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10 X users
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1 patent
wikipedia
1 Wikipedia page
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6 YouTube creators

Citations

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84 Dimensions

Readers on

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241 Mendeley
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Title
Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study
Published in
Nutrition Journal, October 2017
DOI 10.1186/s12937-017-0275-0
Pubmed ID
Authors

Mei He, Jianqin Sun, Zhuo Qin Jiang, Yue Xin Yang

Abstract

A major protein component of cow's milk is β-casein. The most frequent variants in dairy herds are A1 and A2. Recent studies showed that milk containing A1 β-casein promoted intestinal inflammation and exacerbated gastrointestinal symptoms. However, the acute gastrointestinal effects of A1 β-casein have not been investigated. This study compared the gastrointestinal effects of milk containing A1 and A2 β-casein versus A2 β-casein alone in Chinese adults with self-reported lactose intolerance. In this randomised, crossover, double-blind trial, with a 3-day dairy washout period at baseline, subjects were randomised to consume 300 mL of milk containing A1 and A2 β-casein (ratio 58:42; conventional milk) or A2 β-casein alone; subjects consumed the alternative product after a 7-day washout period. Urine galactose was measured at baseline after a 15 g lactose load. Subjects completed 9-point visual analogue scales for gastrointestinal symptoms (borborygmus, flatulence, bloating, abdominal pain, stool frequency, and stool consistency) at baseline and at 1, 3, and 12 h after milk consumption. A total of 600 subjects were included. All six symptom scores at 1 and 3 h were significantly lower after consuming A2 β-casein versus conventional milk (all P<0.0001). At 12 h, significant differences remained for bloating, abdominal pain, stool frequency, and stool consistency (all P<0.0001). Symptom scores were consistently lower with A2 β-casein in both lactose absorbers (urinary galactose ≥0.27 mmol/L) and lactose malabsorbers (urinary galactose <0.27 mmol/L). Milk containing A2 β-casein attenuated acute gastrointestinal symptoms of milk intolerance, while conventional milk containing A1 β-casein reduced lactase activity and increased gastrointestinal symptoms compared with milk containing A2 β-casein. Thus, milk-related gastrointestinal symptoms may result from the ingestion of A1 β-casein rather than lactose in some individuals. NCT02878876 , registered August 16, 2016. Retrospectively registered.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 241 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 241 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 48 20%
Researcher 25 10%
Student > Master 24 10%
Other 11 5%
Student > Postgraduate 10 4%
Other 34 14%
Unknown 89 37%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 15%
Medicine and Dentistry 31 13%
Nursing and Health Professions 25 10%
Biochemistry, Genetics and Molecular Biology 23 10%
Veterinary Science and Veterinary Medicine 6 2%
Other 27 11%
Unknown 93 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 488. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2024.
All research outputs
#54,182
of 25,446,666 outputs
Outputs from Nutrition Journal
#18
of 1,523 outputs
Outputs of similar age
#1,106
of 338,438 outputs
Outputs of similar age from Nutrition Journal
#1
of 21 outputs
Altmetric has tracked 25,446,666 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,523 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.