Modelling dominance in a flexible intercross analysis
BMC Genetics, June 2009
Lars Rönnegård, Francois Besnier, Örjan Carlborg
The aim of this paper is to develop a flexible model for analysis of quantitative trait loci (QTL) in outbred line crosses, which includes both additive and dominance effects. Our flexible intercross analysis (FIA) model accounts for QTL that are not fixed within founder lines and is based on the variance component framework. Genome scans with FIA are performed using a score statistic, which does not require variance component estimation.
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