Title |
Targeting protein quality control pathways in breast cancer
|
---|---|
Published in |
BMC Biology, November 2017
|
DOI | 10.1186/s12915-017-0449-4 |
Pubmed ID | |
Authors |
Sara Sannino, Jeffrey L. Brodsky |
Abstract |
The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiquitin-proteasome or autophagy pathway. Stress response pathway induction is also important for cancer cell survival. Indeed, validated targets for anti-cancer treatments include molecular chaperones, components of the unfolded protein response, the ubiquitin-proteasome system, and autophagy. We will focus on links between breast cancer and these processes, as well as the development of drug resistance, relapse, and treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 8% |
United States | 2 | 8% |
Colombia | 1 | 4% |
Lebanon | 1 | 4% |
India | 1 | 4% |
Nigeria | 1 | 4% |
Estonia | 1 | 4% |
Brazil | 1 | 4% |
Australia | 1 | 4% |
Other | 0 | 0% |
Unknown | 13 | 54% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 58% |
Scientists | 6 | 25% |
Science communicators (journalists, bloggers, editors) | 3 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 19% |
Student > Bachelor | 9 | 14% |
Student > Ph. D. Student | 7 | 11% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 4 | 6% |
Other | 10 | 16% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 26 | 41% |
Medicine and Dentistry | 5 | 8% |
Agricultural and Biological Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 5 | 8% |
Unknown | 17 | 27% |