↓ Skip to main content

Targeting deubiquitinating enzymes in cancer stem cells

Overview of attention for article published in Cancer Cell International, November 2017
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
1 tweeter
patent
6 patents

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
24 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Targeting deubiquitinating enzymes in cancer stem cells
Published in
Cancer Cell International, November 2017
DOI 10.1186/s12935-017-0472-0
Pubmed ID
Authors

Hu Lei, Huizhuang Shan, Yingli Wu

Abstract

Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused on the DUBs regulation of stem cell fate determination. For example, we discuss deubiquitinase inhibition may lead stem cell transcription factors and CSCs-related protein degradation. Also, CSCs microenvironment is regulated by DUBs activity. Our review provides a new insight into DUBs activity by emphasizing their cellular role in regulating stem cell fate and illustrates the opportunities for the application of DUBs inhibitors in the CSC-targeted therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Other 2 8%
Student > Master 2 8%
Researcher 2 8%
Student > Doctoral Student 2 8%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 38%
Agricultural and Biological Sciences 5 21%
Medicine and Dentistry 2 8%
Immunology and Microbiology 1 4%
Unknown 7 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2021.
All research outputs
#6,137,770
of 19,555,311 outputs
Outputs from Cancer Cell International
#108
of 1,320 outputs
Outputs of similar age
#101,637
of 279,796 outputs
Outputs of similar age from Cancer Cell International
#7
of 58 outputs
Altmetric has tracked 19,555,311 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,320 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,796 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.