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Anatomy of enzyme channels

Overview of attention for article published in BMC Bioinformatics, November 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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11 X users
wikipedia
6 Wikipedia pages
googleplus
1 Google+ user

Citations

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88 Dimensions

Readers on

mendeley
139 Mendeley
citeulike
2 CiteULike
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Title
Anatomy of enzyme channels
Published in
BMC Bioinformatics, November 2014
DOI 10.1186/s12859-014-0379-x
Pubmed ID
Authors

Lukáš Pravda, Karel Berka, Radka Svobodová Vařeková, David Sehnal, Pavel Banáš, Roman A Laskowski, Jaroslav Koča, Michal Otyepka

Abstract

BackgroundEnzyme active sites can be connected to the exterior environment by one or more channels passing through the protein. Despite our current knowledge of enzyme structure and function, surprisingly little is known about how often channels are present or about any structural features such channels may have in common.ResultsHere, we analyze the long channels (i.e. >15 Å) leading to the active sites of 4,306 enzyme structures. We find that over 64% of enzymes contain two or more long channels, their typical length being 28 Å. We show that amino acid compositions of the channel significantly differ both to the composition of the active site, surface and interior of the protein.ConclusionsThe majority of enzymes have buried active sites accessible via a network of access channels. This indicates that enzymes tend to have buried active sites, with channels controlling access to, and egress from, them, and that suggests channels may play a key role in helping determine enzyme substrate.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 5 4%
India 1 <1%
United Kingdom 1 <1%
Unknown 132 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 23%
Researcher 22 16%
Student > Bachelor 18 13%
Student > Master 16 12%
Student > Doctoral Student 8 6%
Other 17 12%
Unknown 26 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 34 24%
Chemistry 31 22%
Agricultural and Biological Sciences 21 15%
Computer Science 8 6%
Chemical Engineering 5 4%
Other 12 9%
Unknown 28 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2021.
All research outputs
#2,635,744
of 22,689,790 outputs
Outputs from BMC Bioinformatics
#861
of 7,255 outputs
Outputs of similar age
#39,114
of 362,292 outputs
Outputs of similar age from BMC Bioinformatics
#22
of 141 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,255 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,292 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.