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Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein

Overview of attention for article published in Virology Journal, November 2014
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Title
Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein
Published in
Virology Journal, November 2014
DOI 10.1186/s12985-014-0191-2
Pubmed ID
Authors

Adam B Shapiro, Ning Gao, Nichole O’Connell, Jun Hu, Jason Thresher, Rong-Fang Gu, Ross Overman, Ian M Hardern, Graham G Sproat

Abstract

There are no approved small molecule drug therapies for human respiratory syncytial virus (hRSV), a cause of morbidity and mortality in at-risk newborns, the immunocompromised, and the elderly. We have investigated as a potential novel hRSV drug target the protein-protein interaction between the C-terminus of the viral phosphoprotein (P) and the viral nucleocapsid protein (N), components of the ribonucleoprotein complex that contains, replicates, and transcribes the viral RNA genome. Earlier work by others established that the 9 C-terminal residues of P are necessary and sufficient for binding to N.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Researcher 4 20%
Student > Master 3 15%
Student > Bachelor 1 5%
Other 1 5%
Other 1 5%
Unknown 4 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 20%
Agricultural and Biological Sciences 4 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Medicine and Dentistry 2 10%
Immunology and Microbiology 1 5%
Other 2 10%
Unknown 5 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2014.
All research outputs
#15,310,749
of 22,771,140 outputs
Outputs from Virology Journal
#1,957
of 3,040 outputs
Outputs of similar age
#214,221
of 362,502 outputs
Outputs of similar age from Virology Journal
#49
of 54 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,040 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,502 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.