Title |
Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein
|
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Published in |
Virology Journal, November 2014
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DOI | 10.1186/s12985-014-0191-2 |
Pubmed ID | |
Authors |
Adam B Shapiro, Ning Gao, Nichole O’Connell, Jun Hu, Jason Thresher, Rong-Fang Gu, Ross Overman, Ian M Hardern, Graham G Sproat |
Abstract |
There are no approved small molecule drug therapies for human respiratory syncytial virus (hRSV), a cause of morbidity and mortality in at-risk newborns, the immunocompromised, and the elderly. We have investigated as a potential novel hRSV drug target the protein-protein interaction between the C-terminus of the viral phosphoprotein (P) and the viral nucleocapsid protein (N), components of the ribonucleoprotein complex that contains, replicates, and transcribes the viral RNA genome. Earlier work by others established that the 9 C-terminal residues of P are necessary and sufficient for binding to N. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 30% |
Researcher | 4 | 20% |
Student > Master | 3 | 15% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 20% |
Agricultural and Biological Sciences | 4 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Immunology and Microbiology | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 25% |