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Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients

Overview of attention for article published in Diagnostic Pathology, November 2014
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  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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6 X users

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36 Mendeley
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Title
Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients
Published in
Diagnostic Pathology, November 2014
DOI 10.1186/s13000-014-0198-4
Pubmed ID
Authors

Dan Zhu, Hui Chen, Xiguang Yang, Weisong Chen, Linying Wang, Jilin Xu, Long Yu

Abstract

BackgroundMicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non¿small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development.MethodsUsing real-time quantitative RT-PCR, we detected miR-224 expression in NSCLC cell lines and primary tumor tissues. The association of miR-224 expression with clinicopathological factors and prognosis was also statistically analyzed. MTT, flow cytometric, Transwell invasion and migration assays, and scratch migration assay were used to test the proliferation, apoptosis, invasion, and migration of NSCLC cells after miR-224 mimics transfection.ResultsMiR-224 expression levels were significantly down-regulated in NSCLC compared to the corresponding noncancerous lung tissues (P <0.001). In addition, decreased miR-224 expression was significantly associated with lymph node metastasis (P =0.002), advanced TNM stage (P <0.001), and shorter overall survival (P <0.001). Multivariate regression analysis corroborated that down-regulation of miR-224 was an independent unfavourable prognostic factor for patients with NSCLC. Furthermore, transfection of miR-224 mimics in NSCLC A549 cells was able to reduce cell proliferation, invasion, and migration, and promote cell apoptosis.ConclusionsThese findings indicate that miR-224 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for miR-based therapy of NSCLC.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_198.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 8 22%
Student > Bachelor 5 14%
Student > Master 3 8%
Student > Doctoral Student 2 6%
Other 6 17%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 14 39%
Biochemistry, Genetics and Molecular Biology 8 22%
Agricultural and Biological Sciences 3 8%
Computer Science 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2014.
All research outputs
#7,785,985
of 25,394,081 outputs
Outputs from Diagnostic Pathology
#198
of 1,193 outputs
Outputs of similar age
#99,827
of 370,020 outputs
Outputs of similar age from Diagnostic Pathology
#4
of 41 outputs
Altmetric has tracked 25,394,081 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.