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A gene therapy induced emphysema model and the protective role of stem cells

Overview of attention for article published in Diagnostic Pathology, November 2014
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Title
A gene therapy induced emphysema model and the protective role of stem cells
Published in
Diagnostic Pathology, November 2014
DOI 10.1186/s13000-014-0195-7
Pubmed ID
Authors

Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Haidong Huang, Despoina Sahpatzidou, Lutz Freitag, Leonidas Sakkas, Aggeliki Rapti, Ioannis Kioumis, Georgia Pitsiou, Kokkona Kouzi-Koliakos, Anna Papamichail, Antonis Papaiwannou, Theodora Tsiouda, Kosmas Tsakiridis, Konstantinos Porpodis, Sofia Lampaki, John Organtzis, Andreas Gschwendtner, Konstantinos Zarogoulidis

Abstract

BackgroundChronic obstructive pulmonary disease presents with two different phenotypes: chronic bronchitis and emphysema with parenchymal destruction. Decreased expression of vascular endothelial growth factor and increased endothelial cell apoptosis are considered major factors for emphysema. Stem cells have the ability of vascular regeneration and function as a repair mechanism for the damaged endothelial cells. Currently, minimally invasive interventional procedures such as placement of valves, bio-foam or coils are performed in order to improve the disturbed mechanical function in emphysema patients. However, these procedures cannot restore functional lung tissue. Additionally stem cell instillation into the parenchyma has been used in clinical studies aiming to improve overall respiratory function and quality of life.MethodsIn our current experiment we induced emphysema with a DDMC non-viral vector in BALBC mice and simultaneously instilled stem cells testing the hyposthesis that they might have a protective role against the development of emphysema. The mice were divided into four groups: a) control, b) 50.000 cells, c) 75.000 and d) 100.000 cells.ResultsLung pathological findings revealed that all treatment groups had less damage compared to the control group. Additionally, we observed that emphysema lesions were less around vessels in an area of 10 ¿m.ConclusionsOur findings indicate that stem cell instillation can have a regenerative role if applied upon a tissue scaffold with vessel around.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_195.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 21%
Student > Ph. D. Student 3 13%
Unspecified 2 8%
Professor > Associate Professor 2 8%
Student > Master 1 4%
Other 3 13%
Unknown 8 33%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Unspecified 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Nursing and Health Professions 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 8%
Unknown 10 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2022.
All research outputs
#17,732,540
of 22,771,140 outputs
Outputs from Diagnostic Pathology
#673
of 1,123 outputs
Outputs of similar age
#173,938
of 258,049 outputs
Outputs of similar age from Diagnostic Pathology
#33
of 46 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.