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TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus

Overview of attention for article published in Genes & Nutrition, November 2014
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1 tweeter
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Citations

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30 Mendeley
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Title
TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus
Published in
Genes & Nutrition, November 2014
DOI 10.1007/s12263-014-0440-4
Pubmed ID
Authors

Anna Chu, Meika Foster, Dale Hancock, Kim Bell-Anderson, Peter Petocz, Samir Samman

Abstract

Chronic low-grade inflammation in type 2 diabetes mellitus (DM) can elicit changes in whole-body zinc metabolism. The interaction among the expression of inflammatory cytokines, zinc transporter and metallothionein (MT) genes in peripheral blood mononuclear cells in type 2 DM remains unclear. In a 12-week randomized controlled trial, the effects of zinc (40 mg/day) supplementation on the gene expression of cytokines, zinc transporters and MT in women with type 2 DM were examined. In the zinc-supplemented group, gene expression of tumour necrosis factor (TNF)-α tended to be upregulated by 27 ± 10 % at week 12 compared to baseline (P = 0.053). TNF-α fold change in the zinc-treated group was higher than in those without zinc supplementation (P < 0.05). No significant changes were observed in the expression or fold change of interleukin (IL)-1β or IL-6. Numerous bivariate relationships were observed between the fold changes of cytokines and zinc transporters, including ZnT7 with IL-1β (P < 0.01), IL-6 (P < 0.01) and TNF-α (P < 0.01). In multiple regression analysis, IL-1β expression was predicted by the expression of all zinc transporters and MT measured at baseline (r (2) = 0.495, P < 0.05) and at week 12 (r (2) = 0.532, P < 0.03). The current study presents preliminary evidence that zinc supplementation increases cytokine gene expression in type 2 DM. The relationships found among zinc transporters, MT and cytokines suggest close  interactions between zinc homeostasis and inflammation.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 27%
Student > Master 5 17%
Student > Bachelor 5 17%
Student > Doctoral Student 2 7%
Professor 2 7%
Other 6 20%
Unknown 2 7%
Readers by discipline Count As %
Medicine and Dentistry 10 33%
Agricultural and Biological Sciences 6 20%
Nursing and Health Professions 5 17%
Biochemistry, Genetics and Molecular Biology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2015.
All research outputs
#9,560,611
of 12,445,334 outputs
Outputs from Genes & Nutrition
#225
of 315 outputs
Outputs of similar age
#173,631
of 279,970 outputs
Outputs of similar age from Genes & Nutrition
#14
of 16 outputs
Altmetric has tracked 12,445,334 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 315 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,970 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.