Title |
Adenosine stress native T1 mapping in severe aortic stenosis: evidence for a role of the intravascular compartment on myocardial T1 values
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Published in |
Critical Reviews in Diagnostic Imaging, November 2014
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DOI | 10.1186/s12968-014-0092-y |
Pubmed ID | |
Authors |
Masliza Mahmod, Stefan K Piechnik, Eylem Levelt, Vanessa M Ferreira, Jane M Francis, Andrew Lewis, Nikhil Pal, Sairia Dass, Houman Ashrafian, Stefan Neubauer, Theodoros D Karamitsos |
Abstract |
Myocardial T1 relaxation times have been reported to be markedly abnormal in diverse myocardial pathologies, ascribed to interstitial changes, evaluated by T1 mapping and calculation of extracellular volume (ECV). T1 mapping is sensitive to myocardial water content of both intra- and extracellular in origin, but the effect of intravascular compartment changes on T1 has been largely neglected. We aimed to assess the role of intravascular compartment on native (pre-contrast) T1 values by studying the effect of adenosine-induced vasodilatation in patients with severe aortic stenosis (AS) before and after aortic valve replacement (AVR). |
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