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A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, July 2014
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Title
A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial
Published in
Trials, July 2014
DOI 10.1186/1745-6215-15-271
Pubmed ID
Authors

Karen M Barlow, Brian L Brooks, Frank P MacMaster, Adam Kirton, Trevor Seeger, Michael Esser, Susan Crawford, Alberto Nettel-Aguirre, Roger Zemek, Mikrogianakis Angelo, Valerie Kirk, Carolyn A Emery, David Johnson, Michael D Hill, Jeff Buchhalter, Brenda Turley, Lawrence Richer, Robert Platt, Jamie Hutchison, Deborah Dewey

Abstract

By the age of sixteen, one in five children will sustain a mild traumatic brain injury also known as concussion. Our research found that one in seven school children with mild traumatic brain injury suffer post-concussion syndrome symptoms for three months or longer. Post-concussion syndrome is associated with significant disability in the child and his/her family and yet there are no evidence-based medical treatments available. Melatonin has several potential mechanisms of action that could be useful following mild traumatic brain injury, including neuroprotective effects. The aim of this study is to determine if treatment with melatonin improves post-concussion syndrome in youths following mild traumatic brain injury. Our hypothesis is that treatment of post-concussion syndrome following mild traumatic brain injury with 3 or 10 mg of sublingual melatonin for 28 days will result in a decrease in post-concussion syndrome symptoms compared with placebo.

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Mendeley readers

The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Spain 1 <1%
Canada 1 <1%
Unknown 242 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 40 16%
Student > Master 28 11%
Researcher 25 10%
Student > Ph. D. Student 23 9%
Other 22 9%
Other 53 22%
Unknown 55 22%
Readers by discipline Count As %
Medicine and Dentistry 61 25%
Psychology 34 14%
Neuroscience 31 13%
Nursing and Health Professions 17 7%
Agricultural and Biological Sciences 9 4%
Other 25 10%
Unknown 69 28%