Title |
A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial
|
---|---|
Published in |
Trials, July 2014
|
DOI | 10.1186/1745-6215-15-271 |
Pubmed ID | |
Authors |
Karen M Barlow, Brian L Brooks, Frank P MacMaster, Adam Kirton, Trevor Seeger, Michael Esser, Susan Crawford, Alberto Nettel-Aguirre, Roger Zemek, Mikrogianakis Angelo, Valerie Kirk, Carolyn A Emery, David Johnson, Michael D Hill, Jeff Buchhalter, Brenda Turley, Lawrence Richer, Robert Platt, Jamie Hutchison, Deborah Dewey |
Abstract |
By the age of sixteen, one in five children will sustain a mild traumatic brain injury also known as concussion. Our research found that one in seven school children with mild traumatic brain injury suffer post-concussion syndrome symptoms for three months or longer. Post-concussion syndrome is associated with significant disability in the child and his/her family and yet there are no evidence-based medical treatments available. Melatonin has several potential mechanisms of action that could be useful following mild traumatic brain injury, including neuroprotective effects. The aim of this study is to determine if treatment with melatonin improves post-concussion syndrome in youths following mild traumatic brain injury. Our hypothesis is that treatment of post-concussion syndrome following mild traumatic brain injury with 3 or 10 mg of sublingual melatonin for 28 days will result in a decrease in post-concussion syndrome symptoms compared with placebo. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 242 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 40 | 16% |
Student > Master | 28 | 11% |
Researcher | 25 | 10% |
Student > Ph. D. Student | 23 | 9% |
Other | 22 | 9% |
Other | 53 | 22% |
Unknown | 55 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 61 | 25% |
Psychology | 34 | 14% |
Neuroscience | 31 | 13% |
Nursing and Health Professions | 17 | 7% |
Agricultural and Biological Sciences | 9 | 4% |
Other | 25 | 10% |
Unknown | 69 | 28% |