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Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation

Overview of attention for article published in Radiation Oncology, November 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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4 tweeters

Citations

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27 Dimensions

Readers on

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32 Mendeley
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Title
Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation
Published in
Radiation Oncology, November 2014
DOI 10.1186/s13014-014-0220-8
Pubmed ID
Authors

Chul Hee Min, Harald Paganetti, Brian A Winey, Judith Adams, Shannon M MacDonald, Nancy J Tarbell, Torunn I Yock

Abstract

BackgroundTo precisely calculate skin dose and thus to evaluate the relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with proton beams.MethodsThe dosimetry and alopecia outcomes of 12 children with medulloblastoma (ages 4-15 years) comprise the study cohort. Permanent alopecia was assessed and graded after completion of the entire therapy. Skin threshold doses of permanent alopecia were calculated based on the skin dose from the craniospinal irradiation (CSI) plan using the concept of generalized equivalent uniform dose (gEUD) and accounting for chemotherapy intensity. Monte Carlo simulations were employed to accurately assess uncertainties due to beam range prediction and secondary particles.ResultsIncreasing the dose of the CSI field or the dose given by the boost field to the posterior fossa increased total skin dose delivered in that region. It was found that permanent alopecia could be correlated with CSI dose with a threshold of about 21 Gy (relative biological effectiveness, RBE) with high dose chemotherapy and 30 Gy(RBE) with conventional chemotherapy.ConclusionsOur results based on 12 patients provide a relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with protons. The alopecia risk as assessed with gEUD could be predicted based on the treatment plan information.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 16%
Student > Master 4 13%
Researcher 3 9%
Student > Ph. D. Student 3 9%
Professor 2 6%
Other 8 25%
Unknown 7 22%
Readers by discipline Count As %
Medicine and Dentistry 12 38%
Nursing and Health Professions 5 16%
Physics and Astronomy 5 16%
Business, Management and Accounting 1 3%
Psychology 1 3%
Other 0 0%
Unknown 8 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2020.
All research outputs
#11,909,959
of 21,321,365 outputs
Outputs from Radiation Oncology
#479
of 1,946 outputs
Outputs of similar age
#152,465
of 346,090 outputs
Outputs of similar age from Radiation Oncology
#54
of 244 outputs
Altmetric has tracked 21,321,365 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,946 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,090 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 244 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.