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Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses

Overview of attention for article published in BMC Cancer, November 2014
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Title
Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses
Published in
BMC Cancer, November 2014
DOI 10.1186/1471-2407-14-857
Pubmed ID
Authors

Lin Jiang, Cécile Campagne, Elisabeth Sundström, Pedro Sousa, Saima Imran, Monika Seltenhammer, Gerli Pielberg, Mats J Olsson, Giorgia Egidy, Leif Andersson, Anna Golovko

Abstract

Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 (STX17), is associated with a very high incidence of cutaneous melanoma, but the molecular mechanism behind the melanomagenesis remains unknown. Here, we investigated the involvement of the ERK pathway in melanoma development in Grey horses.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 24%
Student > Ph. D. Student 5 12%
Student > Master 5 12%
Student > Bachelor 3 7%
Student > Postgraduate 2 5%
Other 5 12%
Unknown 11 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 24%
Biochemistry, Genetics and Molecular Biology 6 15%
Veterinary Science and Veterinary Medicine 6 15%
Medicine and Dentistry 3 7%
Unspecified 1 2%
Other 4 10%
Unknown 11 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2014.
All research outputs
#19,292,491
of 23,881,329 outputs
Outputs from BMC Cancer
#5,591
of 8,483 outputs
Outputs of similar age
#268,942
of 367,403 outputs
Outputs of similar age from BMC Cancer
#119
of 169 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,483 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.