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Cdk5/p35 functions as a crucial regulator of spatial learning and memory

Overview of attention for article published in Molecular Brain, November 2014
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Title
Cdk5/p35 functions as a crucial regulator of spatial learning and memory
Published in
Molecular Brain, November 2014
DOI 10.1186/s13041-014-0082-x
Pubmed ID
Authors

Tomohide Mishiba, Mika Tanaka, Naoki Mita, Xiaojuan He, Kodai Sasamoto, Shigeyoshi Itohara, Toshio Ohshima

Abstract

BackgroundCyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation. In Cdk5 knockout (KO) mice and p35 KO mice, brain development is severely impaired because neuronal migration is impaired and lamination is disrupted. To avoid these developmental confounders, we generated inducible CreER-p35 conditional (cKO) mice to study the role of Cdk5/p35 in higher brain function.ResultsCreER-p35 cKO mice exhibited spatial learning and memory impairments and reduced anxiety-like behavior. These phenotypes resulted from a decrease in the dendritic spine density of CA1 pyramidal neurons and defective long-term depression induction in the hippocampus.ConclusionsTaken together, our findings reveal that Cdk5/p35 regulates spatial learning and memory, implicating Cdk5/p35 as a therapeutic target in neurological disorders.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Researcher 6 11%
Student > Ph. D. Student 6 11%
Student > Bachelor 4 8%
Student > Doctoral Student 4 8%
Other 10 19%
Unknown 15 28%
Readers by discipline Count As %
Neuroscience 14 26%
Agricultural and Biological Sciences 10 19%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 3 6%
Psychology 2 4%
Other 3 6%
Unknown 17 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2014.
All research outputs
#15,310,749
of 22,771,140 outputs
Outputs from Molecular Brain
#671
of 1,106 outputs
Outputs of similar age
#214,163
of 362,492 outputs
Outputs of similar age from Molecular Brain
#15
of 25 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,492 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.