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Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation

Overview of attention for article published in Critical Care, November 2014
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Title
Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation
Published in
Critical Care, November 2014
DOI 10.1186/s13054-014-0636-4
Pubmed ID
Authors

Graeme MacLaren, Paul Monagle

Abstract

A heparin-like effect was recently described in infants, children, and adults receiving bivalirudin while supported on extracorporeal membrane oxygenation following cardiopulmonary bypass. This is most likely due to endogenous release of glycosaminoglycans from vascular endothelium and mast cells and is associated with longer duration of extracorporeal membrane oxygenation and an increased incidence of sepsis. Further investigation into this effect should include patients without recent cardiopulmonary bypass, exclude the presence of covalent antithrombin-heparin complexes, and employ a variety of different heparinases for thromboelastography. The phenomenon may partially explain the heterogeneity of anticoagulation requirements in patients on extracorporeal life support.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 33%
Professor > Associate Professor 3 17%
Student > Doctoral Student 2 11%
Student > Ph. D. Student 2 11%
Other 1 6%
Other 2 11%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 10 56%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Agricultural and Biological Sciences 1 6%
Engineering 1 6%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2014.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Critical Care
#5,970
of 6,554 outputs
Outputs of similar age
#273,913
of 368,878 outputs
Outputs of similar age from Critical Care
#146
of 166 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,878 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.