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HPV infection and triple-negative breast cancers: an Italian case-control study

Overview of attention for article published in Virology Journal, November 2014
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Title
HPV infection and triple-negative breast cancers: an Italian case-control study
Published in
Virology Journal, November 2014
DOI 10.1186/s12985-014-0190-3
Pubmed ID
Authors

Andrea Fausto Piana, Giovanni Sotgiu, Maria Rosaria Muroni, Paolo Cossu-Rocca, Paolo Castiglia, Maria Rosaria De Miglio

Abstract

BackgroundBreast cancer is one of the most important neoplasia among women. To reduce its incidence and mortality impact it would be desirable to early identify risk factors associated with its development. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). No specific relationship with different breast cancer types has been demonstrated until now. In particular, the triple-negative breast cancer (TNBC), characterized by a receptor negative pattern (ER/PgR/HER2¿negative) and poor prognosis, can represent one of the most relevant clinical and public health priority in terms of observational research.FindingsAim of the study was to evaluate the HPV-positivity prevalence in two breast cancer series (TNBC vs. non-TNBC) in Northern Sardinia, Italy. The sample size of each group was represented by 40 formalin-fixed and paraffin-embedded specimens. The mean age was 60.3 years. The majority of the cancers were ductal (84%). The grading distribution was different: G2 was the most prevalent grade in the non-TNBC series, whereas G3 was the most frequent in the TNBC series (70% and 72%, respectively). Six biological samples were HPV-positive (7.5%): the positivity was assessed only in the TNBC group (15%; p-value: 0.026). The isolated genotypes were: 16, 31, 45, 52, 6, and 66. Only one co-infection was found (i.e., HPV-6 and -66).ConclusionsThe prevalence of HPV-positivity in TNBC specimens was 15%. On the basis of its carcinogenetic ability, an etiological role in the pathogenesis of the cancer could be supposed. This association should be confirmed with longitudinal studies to better assess the role of the HPV infection in TNBC and non-TNBC tumors.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Norway 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 20%
Student > Ph. D. Student 7 17%
Student > Doctoral Student 5 12%
Student > Master 5 12%
Professor 4 10%
Other 7 17%
Unknown 5 12%
Readers by discipline Count As %
Medicine and Dentistry 19 46%
Biochemistry, Genetics and Molecular Biology 7 17%
Nursing and Health Professions 5 12%
Agricultural and Biological Sciences 2 5%
Immunology and Microbiology 2 5%
Other 2 5%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2014.
All research outputs
#14,204,846
of 22,771,140 outputs
Outputs from Virology Journal
#1,605
of 3,040 outputs
Outputs of similar age
#191,659
of 361,837 outputs
Outputs of similar age from Virology Journal
#38
of 52 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,040 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,837 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.