Title |
Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration
|
---|---|
Published in |
BMC Cardiovascular Disorders, November 2014
|
DOI | 10.1186/1471-2261-14-165 |
Pubmed ID | |
Authors |
Trevor S Tippetts, Duane R Winden, Adam C Swensen, Michael B Nelson, Mikayla O Thatcher, Rex R Saito, Tyler B Condie, Kurtis J Simmons, Allan M Judd, Paul R Reynolds, Benjamin T Bikman |
Abstract |
Cigarette smoking is a common and lethal worldwide habit, with considerable mortality stemming from its deleterious effects on heart function. While current theories posit altered blood lipids and fibrinogen metabolism as likely mediators, none have explored the role of the sphingolipid ceramide in exacerbating heart function with smoke exposure. Ceramide production is a consequence of cigarette smoke in the lung, and considering ceramide's harmful effects on mitochondrial function, we sought to elucidate the role of ceramide in mediating smoke-induced altered heart mitochondrial respiration. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 27% |
Student > Doctoral Student | 4 | 12% |
Student > Ph. D. Student | 4 | 12% |
Student > Master | 4 | 12% |
Student > Bachelor | 3 | 9% |
Other | 3 | 9% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 27% |
Agricultural and Biological Sciences | 4 | 12% |
Nursing and Health Professions | 3 | 9% |
Immunology and Microbiology | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 5 | 15% |
Unknown | 7 | 21% |