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Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration

Overview of attention for article published in BMC Cardiovascular Disorders, November 2014
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Title
Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration
Published in
BMC Cardiovascular Disorders, November 2014
DOI 10.1186/1471-2261-14-165
Pubmed ID
Authors

Trevor S Tippetts, Duane R Winden, Adam C Swensen, Michael B Nelson, Mikayla O Thatcher, Rex R Saito, Tyler B Condie, Kurtis J Simmons, Allan M Judd, Paul R Reynolds, Benjamin T Bikman

Abstract

Cigarette smoking is a common and lethal worldwide habit, with considerable mortality stemming from its deleterious effects on heart function. While current theories posit altered blood lipids and fibrinogen metabolism as likely mediators, none have explored the role of the sphingolipid ceramide in exacerbating heart function with smoke exposure. Ceramide production is a consequence of cigarette smoke in the lung, and considering ceramide's harmful effects on mitochondrial function, we sought to elucidate the role of ceramide in mediating smoke-induced altered heart mitochondrial respiration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 27%
Student > Doctoral Student 4 12%
Student > Ph. D. Student 4 12%
Student > Master 4 12%
Student > Bachelor 3 9%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 9 27%
Agricultural and Biological Sciences 4 12%
Nursing and Health Professions 3 9%
Immunology and Microbiology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 5 15%
Unknown 7 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2018.
All research outputs
#16,099,609
of 23,881,329 outputs
Outputs from BMC Cardiovascular Disorders
#882
of 1,726 outputs
Outputs of similar age
#220,140
of 367,124 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#22
of 32 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,726 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,124 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.