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Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

Overview of attention for article published in Genome Medicine, October 2014
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Title
Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity
Published in
Genome Medicine, October 2014
DOI 10.1186/s13073-014-0088-0
Pubmed ID
Authors

Barbara Hrdlickova, Vinod Kumar, Kartiek Kanduri, Daria V Zhernakova, Subhash Tripathi, Juha Karjalainen, Riikka J Lund, Yang Li, Ubaid Ullah, Rutger Modderman, Wayel Abdulahad, Harri Lähdesmäki, Lude Franke, Riitta Lahesmaa, Cisca Wijmenga, Sebo Withoff

Abstract

Although genome-wide association studies (GWAS) have identified hundreds of variants associated with a risk for autoimmune and immune-related disorders (AID), our understanding of the disease mechanisms is still limited. In particular, more than 90% of the risk variants lie in non-coding regions, and almost 10% of these map to long non-coding RNA transcripts (lncRNAs). lncRNAs are known to show more cell-type specificity than protein-coding genes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
Mexico 1 <1%
Germany 1 <1%
Canada 1 <1%
Unknown 143 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 28%
Researcher 38 26%
Student > Master 14 9%
Student > Postgraduate 8 5%
Other 8 5%
Other 20 14%
Unknown 19 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 45 30%
Agricultural and Biological Sciences 42 28%
Medicine and Dentistry 22 15%
Immunology and Microbiology 7 5%
Neuroscience 2 1%
Other 8 5%
Unknown 22 15%