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Submandibular gland-sparing radiation therapy for locally advanced oropharyngeal squamous cell carcinoma: patterns of failure and xerostomia outcomes

Overview of attention for article published in Radiation Oncology, November 2014
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Title
Submandibular gland-sparing radiation therapy for locally advanced oropharyngeal squamous cell carcinoma: patterns of failure and xerostomia outcomes
Published in
Radiation Oncology, November 2014
DOI 10.1186/s13014-014-0255-x
Pubmed ID
Authors

Michael F Gensheimer, Jay J Liao, Adam S Garden, George E Laramore, Upendra Parvathaneni

Abstract

BackgroundSaliva from submandibular glands (SMG) is necessary to minimize xerostomia. It is unclear whether SMG can be safely spared in patients undergoing bilateral neck radiotherapy for locally advanced oropharyngeal cancer without increasing the risk of marginal recurrence. We evaluated the outcomes of contralateral submandibular gland (cSMG) sparing intensity-modulated radiation therapy (IMRT).MethodsAll patients with stage III/IV oropharyngeal squamous cell carcinoma treated with bilateral neck IMRT from 2006¿2012 at our institution were included. Appropriately selected patients with favorable primary tumor characteristics and no definite contralateral neck disease were treated with cSMG-sparing IMRT. Patterns of failure and xerostomia outcomes were retrospectively analyzed.Results114 patients were treated. 89% had stage IV disease and 89% received definitive radiation therapy. 76 patients (67%) received cSMG sparing IMRT. With a median follow-up of 30 months, there were 10 local, 9 regional, and 10 distant recurrences. 2-year overall survival was 86% and 2-year loco-regional control was 87%. In cSMG spared patients, the mean cSMG dose was 30.7 Gy. Late grade 2+ xerostomia was significantly reduced in the cSMG spared group compared to those without SMG sparing (6 months: 23% vs. 72%, 12 months: 6% vs. 41%, 24 months: 3% vs. 36%, all p¿<¿0.0007). There were no peri-SMG marginal recurrences in the cSMG-spared cohort.ConclusionscSMG sparing IMRT did not increase marginal failures in this series of locally advanced oropharyngeal SCC patients. Xerostomia was significantly reduced in cSMG spared patients.

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Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 23%
Student > Ph. D. Student 6 14%
Student > Bachelor 5 11%
Other 5 11%
Researcher 4 9%
Other 9 20%
Unknown 5 11%
Readers by discipline Count As %
Medicine and Dentistry 22 50%
Physics and Astronomy 6 14%
Nursing and Health Professions 3 7%
Agricultural and Biological Sciences 2 5%
Mathematics 1 2%
Other 4 9%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2021.
All research outputs
#16,194,891
of 20,141,442 outputs
Outputs from Radiation Oncology
#1,298
of 1,872 outputs
Outputs of similar age
#241,430
of 338,494 outputs
Outputs of similar age from Radiation Oncology
#209
of 243 outputs
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