Title |
Concurrent transcriptional profiling of Dirofilaria immitis and its Wolbachia endosymbiont throughout the nematode life cycle reveals coordinated gene expression
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Published in |
BMC Genomics, November 2014
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DOI | 10.1186/1471-2164-15-1041 |
Pubmed ID | |
Authors |
Ashley N Luck, Christopher C Evans, Molly D Riggs, Jeremy M Foster, Andrew R Moorhead, Barton E Slatko, Michelle L Michalski |
Abstract |
Dirofilaria immitis, or canine heartworm, is a filarial nematode parasite that infects dogs and other mammals worldwide. Current disease control relies on regular administration of anthelmintic preventives, however, relatively poor compliance and evidence of developing drug resistance could warrant alternative measures against D. immitis and related human filarial infections be taken. As with many other filarial nematodes, D. immitis contains Wolbachia, an obligate bacterial endosymbiont thought to be involved in providing certain critical metabolites to the nematode. Correlations between nematode and Wolbachia transcriptomes during development have not been examined. Therefore, we detailed the developmental transcriptome of both D. immitis and its Wolbachia (wDi) in order to gain a better understanding of parasite-endosymbiont interactions throughout the nematode life cycle. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 25% |
United States | 2 | 17% |
France | 2 | 17% |
Canada | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 67% |
Scientists | 3 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 1% |
Czechia | 1 | 1% |
Unknown | 74 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 22% |
Student > Master | 14 | 18% |
Researcher | 14 | 18% |
Student > Bachelor | 5 | 7% |
Professor | 2 | 3% |
Other | 4 | 5% |
Unknown | 20 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 28% |
Biochemistry, Genetics and Molecular Biology | 14 | 18% |
Veterinary Science and Veterinary Medicine | 5 | 7% |
Immunology and Microbiology | 4 | 5% |
Medicine and Dentistry | 4 | 5% |
Other | 8 | 11% |
Unknown | 20 | 26% |