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Solitary fibrous tumor – clinicopathologic, immunohistochemical and molecular analysis of 28 cases

Overview of attention for article published in Diagnostic Pathology, November 2014
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Title
Solitary fibrous tumor – clinicopathologic, immunohistochemical and molecular analysis of 28 cases
Published in
Diagnostic Pathology, November 2014
DOI 10.1186/s13000-014-0224-6
Pubmed ID
Authors

Rob JC Vogels, Myrella Vlenterie, Yvonne MH Versleijen-Jonkers, Emiel Ruijter, Elise M Bekers, Marian AJ Verdijk, Monique M Link, Johannes J Bonenkamp, Winette TA van der Graaf, Pieter J Slootweg, Albert JH Suurmeijer, Patricia JTA Groenen, Uta Flucke

Abstract

BackgroundSolitary fibrous tumor is a mesenchymal tumor of fibroblastic type, which can affect any region of the body. Recently, a recurrent gene fusion NAB2-STAT6 has been identified as molecular hallmark. The NAB2-STAT6 fusion leads to EGR1 activation and transcriptional deregulation of EGR1-dependent target genes and is a driving event in initiation of SFT. In this study, we report the clinicopathologic and RT-PCR findings and evaluated expression of STAT6 and EGR1 protein in a cohort of 28 SFTs.Methods28 patients with a median age of 54 years were included with SFTs originating at different sites, most occurring in the lung and pleura (9, 32%), 5 in soft tissues of the lower extremities (18%) and 5 in the head and neck (18%). For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues. Immunohistochemistry was performed on all cases with antibodies against STAT6 and EGR1.ResultsAll patients were treated by surgery, 3 with adjuvant chemo- or radiotherapy. Follow-up data of 18 patients could be obtained of which 2 patients died of metastatic disease 13 months and 52 years after first diagnosis. Sixteen patients have no evidence of disease with a median follow up of 29.5 months (range 7 ¿ 120 months). NAB2-STAT6 fusion transcripts were found in 19/28 cases (68%). The most common fusion was between NAB2 exon 4 and STAT6 exon 3 (11/19, 58%), mainly occurring in pleuropulmonary lesions. All cases showed strong nuclear expression of STAT6 (28/28, 100%) while EGR1 showed low-level variable nuclear expression in all samples, comparable with the EGR1 expression results of the control group.ConclusionsThe identification of the NAB2-STAT6 fusion in SFTs can provide important diagnostic information, especially in cases with aberrant morphology or when biopsy material is limited. STAT6 immunohistochemistry is another useful tool in diagnosing SFT. EGR1 immunohistochemistry indicates low-level protein expression in accordance with EGR1 activation due to distorted NAB2 activity.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_224.

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Mendeley readers

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The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 59 97%

Demographic breakdown

Readers by professional status Count As %
Other 12 20%
Student > Postgraduate 12 20%
Student > Bachelor 6 10%
Researcher 6 10%
Student > Doctoral Student 5 8%
Other 8 13%
Unknown 12 20%
Readers by discipline Count As %
Medicine and Dentistry 33 54%
Psychology 3 5%
Agricultural and Biological Sciences 2 3%
Computer Science 1 2%
Immunology and Microbiology 1 2%
Other 4 7%
Unknown 17 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2014.
All research outputs
#13,417,604
of 22,772,779 outputs
Outputs from Diagnostic Pathology
#348
of 1,123 outputs
Outputs of similar age
#178,431
of 361,775 outputs
Outputs of similar age from Diagnostic Pathology
#14
of 54 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,775 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.