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Diverse expression of selected cytokines and proteinases in synovial fluid obtained from osteoarthritic and healthy human knee joints

Overview of attention for article published in European Journal of Medical Research, November 2014
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Title
Diverse expression of selected cytokines and proteinases in synovial fluid obtained from osteoarthritic and healthy human knee joints
Published in
European Journal of Medical Research, November 2014
DOI 10.1186/s40001-014-0065-5
Pubmed ID
Authors

Martin Sauerschnig, Josef Stolberg-Stolberg, Anne Schulze, Gian Max Salzmann, Carsten Perka, Christian Jiri Dynybil

Abstract

BackgroundOsteoarthritis (OA) is defined by signs and symptoms of inflammation within the affected joint. The aim of this study is to determine the mRNA expression levels of selected cytokines and matrix-metalloproteinases of cells found in synovial fluid (SF) obtained from osteoarthritic knee joints compared to healthy controls.MethodsSF was obtained from 40 patients undergoing total knee arthroplasty due to evident OA and from 10 healthy controls. Expression of TNF-¿, IL-1ß, MMP-1 and MMP-3 was assayed among both groups by performing qPCR. Patients were configured concerning age, gender and BMI.ResultsIL-1ß, MMP-1 and MMP-3 showed significantly higher expression among the OA group compared to control (P¿<¿0.001). Strong correlation appeared between expression of MMP-1 and MMP-3 among OA patients (r¿=¿0.856); no correlation was found between age, gender or BMI and cytokine/proteinase expression. Expression of IL-1ß, MMP-1 and MMP-3 within SF was elevated in OA-patients.ConclusionConsequently, cells within SF expressing cytokines and proteinases may play a relevant role in the progression of joint destruction. Considering the fact that SF in an OA joint comprises abnormal amounts of detrimental bioactive proteins, temporary clearance, dilution or suppression/modulation by means of lavage or disease-modifying medication may be promising to constitute interim relief or even postpone disease progression due to decreased inflammatory and/or degrading activity within the articular environment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 15%
Other 3 11%
Student > Ph. D. Student 3 11%
Professor > Associate Professor 2 7%
Student > Bachelor 1 4%
Other 4 15%
Unknown 10 37%
Readers by discipline Count As %
Medicine and Dentistry 8 30%
Agricultural and Biological Sciences 3 11%
Chemical Engineering 1 4%
Immunology and Microbiology 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 7%
Unknown 11 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2014.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from European Journal of Medical Research
#730
of 924 outputs
Outputs of similar age
#315,928
of 369,816 outputs
Outputs of similar age from European Journal of Medical Research
#7
of 7 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 924 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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