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Food allergy enhances allergic asthma in mice

Overview of attention for article published in Respiratory Research, November 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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7 tweeters
patent
1 patent
googleplus
1 Google+ user

Citations

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23 Dimensions

Readers on

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57 Mendeley
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Title
Food allergy enhances allergic asthma in mice
Published in
Respiratory Research, November 2014
DOI 10.1186/s12931-014-0142-x
Pubmed ID
Authors

Tiphaine Bihouée, Gregory Bouchaud, Julie Chesné, David Lair, Camille Rolland-Debord, Faouzi Braza, Marie-Aude Cheminant, Philippe Aubert, Guillaume Mahay, Christine Sagan, Michel Neunlist, Sophie Brouard, Marie Bodinier, Antoine Magnan

Abstract

BackgroundAtopic march refers to the typical transition from a food allergy in early childhood to allergic asthma in older children and adults. However the precise interplay of events involving gut, skin and pulmonary inflammation in this process is not completely understood.ObjectivesTo develop a mouse model of mixed food and respiratory allergy mimicking the atopic march and better understand the impact of food allergies on asthma.MethodsFood allergy to ovalbumin (OVA) was induced through intra-peritoneal sensitization and intra-gastric challenge, and/or a respiratory allergy to house dust mite (HDM) was obtained through percutaneous sensitization and intra-nasal challenges with dermatophagoides farinae (Der f) extract. Digestive, respiratory and systemic parameters were analyzed.ResultsOVA-mediated gut allergy was associated with an increase in jejunum permeability, and a worsening of Der f-induced asthma with stronger airway hyperresponsiveness and pulmonary cell infiltration, notably eosinophils. There was overproduction of the pro-eosinophil chemokine RANTES in broncho-alveolar lavages associated with an enhanced Th2 cytokine secretion and increased total and Der f-specific IgE when the two allergies were present. Both AHR and lung inflammation increased after a second pulmonary challenge.ConclusionGut sensitization to OVA amplifies Der f-induced asthma in mice.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 28%
Researcher 10 18%
Student > Ph. D. Student 7 12%
Student > Doctoral Student 4 7%
Student > Bachelor 4 7%
Other 5 9%
Unknown 11 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 33%
Medicine and Dentistry 10 18%
Biochemistry, Genetics and Molecular Biology 6 11%
Immunology and Microbiology 6 11%
Environmental Science 2 4%
Other 2 4%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2020.
All research outputs
#3,619,567
of 21,321,365 outputs
Outputs from Respiratory Research
#419
of 2,558 outputs
Outputs of similar age
#55,288
of 346,166 outputs
Outputs of similar age from Respiratory Research
#20
of 136 outputs
Altmetric has tracked 21,321,365 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,558 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.