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Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis

Overview of attention for article published in Arthritis Research & Therapy, November 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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4 X users
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2 patents
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1 Facebook page

Citations

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172 Dimensions

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148 Mendeley
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Title
Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis
Published in
Arthritis Research & Therapy, November 2014
DOI 10.1186/s13075-014-0486-0
Pubmed ID
Authors

Matthew L Stoll, Ranjit Kumar, Casey D Morrow, Elliot J Lefkowitz, Xiangqin Cui, Anna Genin, Randy Q Cron, Charles O Elson

Abstract

IntroductionPrior studies have established altered microbiota and immunologic reactivity to enteric commensal organisms in inflammatory bowel disease (IBD). Since intestinal inflammation is present in a subset of patients with both pediatric and adult spondyloarthritis (SpA), we hypothesized that SpA patients may also have altered microbiota and immune responsiveness to enteric organisms.MethodsStool and blood specimens were collected from children with enthesitis-related arthritis (ERA) and non-inflammatory controls. DNA purified from stool was subject to PCR amplification and sequencing of the variable IV region from the 16S rDNA gene. IgA and IgG Enzyme-linked Immunosorbent Assays (ELISAs) were performed on select species of bacteria in most subjects.ResultsTwenty-five children with ERA and 13 controls were included. The ERA patients had less Faecalibacterium prausnitzii (3.8% versus 10%, P =0.008) and lachnospiraceae family (12 versus 7.0%, P =0.020), a statistically significant increase in bifidobacterium (1.8% versus 0%, P =0.032) and a non-statistically significant increase in Bacteroides (21% versus 11%, P =0.150). Akkermansia muciniphila was abundant (>2%) in 7/27 ERA patients but none of the controls (P =0.072.) Cluster analysis revealed two clusters of ERA patients: Cluster one (n =8) was characterized by high levels of Bacteroides genus, while a second (n =15) cluster had similar levels as the controls. Seven of 17 (41%) of the ERA subjects in Cluster 2 compared to 0/8 of the subjects in Cluster 1 had abundant Akkermansia muciniphila (P =0.057). Serum IgA and IgG antibody levels against F. prausnitzii and B. fragilis were similar between patients and controls, whereas the two groups showed divergent responses when the fecal relative abundances of F. prausnitzii and Bacteroides were compared individually against IgA antibody levels recognizing F. prausnitzii and B. fragilis, respectively.ConclusionThe abundance of F. prausnitzii in the stool among patients with ERA is reduced compared to controls, and Bacteroides and A. muciniphila are identified as associative agents in subsets of ERA patients. Differences in the humoral responses to these bacteria may contribute to disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 147 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 22%
Student > Ph. D. Student 19 13%
Other 17 11%
Student > Bachelor 16 11%
Student > Master 14 9%
Other 23 16%
Unknown 27 18%
Readers by discipline Count As %
Medicine and Dentistry 47 32%
Agricultural and Biological Sciences 20 14%
Immunology and Microbiology 18 12%
Biochemistry, Genetics and Molecular Biology 11 7%
Nursing and Health Professions 5 3%
Other 15 10%
Unknown 32 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2020.
All research outputs
#4,191,860
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#944
of 3,381 outputs
Outputs of similar age
#55,531
of 369,509 outputs
Outputs of similar age from Arthritis Research & Therapy
#11
of 53 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,509 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.