Title |
A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E
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Published in |
Biotechnology for Biofuels and Bioproducts, December 2014
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DOI | 10.1186/s13068-014-0165-z |
Pubmed ID | |
Authors |
Sonya M Clarkson, Scott D Hamilton-Brehm, Richard J Giannone, Nancy L Engle, Timothy J Tschaplinski, Robert L Hettich, James G Elkins |
Abstract |
Chemical and physical pretreatment of lignocellulosic biomass improves substrate reactivity for increased microbial biofuel production, but also restricts growth via the release of furan aldehydes, such as furfural and 5-hydroxymethylfurfural (5-HMF). The physiological effects of these inhibitors on thermophilic, fermentative bacteria are important to understand; especially as cellulolytic strains are being developed for consolidated bioprocessing (CBP) of lignocellulosic feedstocks. Identifying mechanisms for detoxification of aldehydes in naturally resistant strains, such as Thermoanaerobacter spp., may also enable improvements in candidate CBP microorganisms. |
X Demographics
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Country | Count | As % |
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United States | 2 | 50% |
Germany | 1 | 25% |
Australia | 1 | 25% |
Demographic breakdown
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Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
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Indonesia | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 31% |
Researcher | 11 | 28% |
Student > Master | 4 | 10% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 8% |
Unknown | 5 | 13% |
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Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Engineering | 3 | 8% |
Environmental Science | 2 | 5% |
Medicine and Dentistry | 2 | 5% |
Other | 5 | 13% |
Unknown | 6 | 15% |