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Mendeley readers
Attention Score in Context
| Title |
Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, February 2017
|
| DOI | 10.1186/s12906-017-1624-4 |
| Pubmed ID | |
| Authors |
William A. Boisvert, Miri Yu, Youngbin Choi, Gi Hee Jeong, Yi-Lin Zhang, Sunghun Cho, Changsun Choi, Sanghyun Lee, Bog-Hieu Lee |
| Abstract |
Geranium sibiricum L. has been used as a medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea. However, its hair growth-promoting effect was not investigated so far. This study examined the effects of Geranium sibiricum L. extract (GSE) on hair growth, using in vitro and in vivo models. Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). Hair-growth promoting effect was measured in animal model. Relative expression of interleukin-1, vascular endothelial growth factor, hepatocyte growth factor, and transforming growth factor beta 1 was determined by real time RT-PCR. Expression of Ki-67 and stem cell factor were analyzed by immunohistochemistry. GSE treatment proliferated and migrated human dermal papilla cells (hDPCs) more than treatment of 10 μM minoxidil. GSE significantly stimulated the expression of Ki-67 protein and the mRNA levels of hepatocyte growth factor and vascular endothelial growth factor in hDPCs. Topical application of 1,000 ppm GSE for 3 weeks promoted more significant hair growth on shaved C57BL/6 mice than did 5% minoxidil. The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. GSE treatment significantly reduced the number of mast cells and the expression of transforming growth factor beta 1 in mouse skin tissues. These results demonstrated that GSE promotes hair growth in vitro and in vivo by regulating growth factors and the cellular response. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Student > Bachelor | 10 | 14% |
| Researcher | 8 | 11% |
| Unspecified | 3 | 4% |
| Other | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 26 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 14% |
| Medicine and Dentistry | 10 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Agricultural and Biological Sciences | 5 | 7% |
| Engineering | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 28 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2024.
All research outputs
#1,033,932
of 25,225,182 outputs
Outputs from BMC Complementary Medicine and Therapies
#159
of 3,940 outputs
Outputs of similar age
#23,061
of 438,417 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#4
of 101 outputs
Altmetric has tracked 25,225,182 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,940 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 438,417 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.