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Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection

Overview of attention for article published in Journal of Neuroinflammation, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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3 tweeters

Citations

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28 Dimensions

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32 Mendeley
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Title
Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection
Published in
Journal of Neuroinflammation, December 2014
DOI 10.1186/s12974-014-0199-y
Pubmed ID
Authors

Joome Suh, Elizabeth Sinclair, Julia Peterson, Evelyn Lee, Tassos C Kyriakides, Fang-yong Li, Lars Hagberg, Dietmar Fuchs, Richard W Price, Magnus Gisslen, Serena Spudich

Abstract

BackgroundCentral nervous system (CNS) inflammation is a mediator of brain injury in HIV infection. To study the natural course of CNS inflammation in the early phase of infection, we analyzed longitudinal levels of soluble and cellular markers of inflammation in cerebrospinal fluid (CSF) and blood, beginning with primary HIV-1 infection (PHI).MethodsAntiretroviral-naïve subjects identified as having PHI (less than one year since HIV transmission) participated in phlebotomy and lumbar puncture at baseline and at variable intervals thereafter. Mixed-effects models were used to analyze longitudinal levels of CSF neopterin and percentages of activated cluster of differentiation (CD)4+ and CD8+ T-cells (co-expressing CD38 and human leukocyte antigen-D-related (HLA-DR)) in blood and CSF.ResultsA total of 81 subjects were enrolled at an average of 100 days after HIV transmission and had an average follow-up period of 321 days, with the number of visits ranging from one to 13. At baseline, the majority of subjects had CSF neopterin concentrations above the upper limit of normal. The baseline concentration was associated with the longitudinal trajectory of CSF neopterin. In subjects with baseline levels of less than 21 nmol/L, a cutoff value obtained from a mixed-effects model, CSF neopterin increased by 2.9% per 10 weeks (n¿=¿33; P <0.001), whereas it decreased by 6.7% in subjects with baseline levels of more than 21 nmol/L (n¿=¿11; P¿=¿0.001). In a subset with available flow cytometry data (n¿=¿42), the percentages of activated CD4+ and CD8+ T-cells in CSF increased by 0.8 (P <0.001) and 0.73 (P¿=¿0.02) per 10 weeks, respectively.ConclusionsNeopterin levels and the percentages of activated CD4+ and CD8+ T-cells in CSF progressively increase in most subjects without treatment during early HIV-1 infection, suggesting an accrual of intrathecal inflammation, a major contributor to neuropathology in HIV infection.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Argentina 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 22%
Student > Ph. D. Student 6 19%
Student > Master 5 16%
Student > Doctoral Student 3 9%
Student > Bachelor 1 3%
Other 1 3%
Unknown 9 28%
Readers by discipline Count As %
Medicine and Dentistry 9 28%
Neuroscience 2 6%
Immunology and Microbiology 2 6%
Agricultural and Biological Sciences 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 13 41%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#7,092,200
of 12,786,466 outputs
Outputs from Journal of Neuroinflammation
#628
of 1,473 outputs
Outputs of similar age
#115,449
of 293,474 outputs
Outputs of similar age from Journal of Neuroinflammation
#36
of 95 outputs
Altmetric has tracked 12,786,466 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,473 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.