Title |
Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis
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Published in |
Critical Care, December 2014
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DOI | 10.1186/s13054-014-0660-4 |
Pubmed ID | |
Authors |
Kim de Haan, AB Johan Groeneveld, Hilde RH de Geus, Mohamud Egal, Ard Struijs |
Abstract |
IntroductionIn Europe, vitamin D deficiency is highly prevalent varying between 40% to 60% in the healthy general adult population. The consequences of vitamin D deficiency for sepsis and outcome in critically ill patients remains controversial. We therefore systematically reviewed observational cohort studies on vitamin D deficiency on the intensive care unit.MethodsFourteen observational reports published from January 2000 to March 2014, retrieved from Pubmed and Embase, involving 9,715 critically ill patients and serum 25-hydroxyvitamin D3 (25 (OH)-D) concentrations, were meta-analysed.ResultsLevels of 25 (OH)-D less than 50 nmol/L were associated with increased rates of infection (risk ratio (RR) 1.49, 95% (confidence interval (CI) 1.12 to 1.99), P =0.007), sepsis (RR 1.46, 95% (CI 1.27 to 1.68), P <0.001), 30-day mortality (RR 1.42, 95% (CI 1.00 to 2.02), P =0.05), and in-hospital mortality (RR 1.79, 95% (CI 1.49 to 2.16), P <0.001). In a subgroup analysis of adjusted data including vitamin D deficiency as a risk factor for 30 day-mortality the pooled RR was 1.76 (95% CI 1.37 to 2.26, P <0.001).ConclusionsThis meta-analysis suggests that vitamin D deficiency increases susceptibility for severe infections and mortality of the critically ill. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 3 | 12% |
Mauritius | 1 | 4% |
Spain | 1 | 4% |
Australia | 1 | 4% |
Germany | 1 | 4% |
Italy | 1 | 4% |
United States | 1 | 4% |
United Kingdom | 1 | 4% |
Greece | 1 | 4% |
Other | 0 | 0% |
Unknown | 14 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 72% |
Practitioners (doctors, other healthcare professionals) | 4 | 16% |
Science communicators (journalists, bloggers, editors) | 2 | 8% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 1 | <1% |
Colombia | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 211 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 31 | 14% |
Student > Master | 28 | 13% |
Student > Bachelor | 22 | 10% |
Other | 20 | 9% |
Student > Ph. D. Student | 15 | 7% |
Other | 50 | 23% |
Unknown | 49 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 93 | 43% |
Nursing and Health Professions | 17 | 8% |
Biochemistry, Genetics and Molecular Biology | 15 | 7% |
Agricultural and Biological Sciences | 8 | 4% |
Engineering | 4 | 2% |
Other | 23 | 11% |
Unknown | 55 | 26% |