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Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Overview of attention for article published in Veterinary Research, December 2014
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Title
Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella
Published in
Veterinary Research, December 2014
DOI 10.1186/s13567-014-0119-2
Pubmed ID
Authors

Ivan Rychlik, Marta Elsheimer-Matulova, Kamila Kyrova

Abstract

Chickens can be infected with Salmonella enterica at any time during their life. However, infections within the first hours and days of their life are epidemiologically the most important, as newly hatched chickens are highly sensitive to Salmonella infection. Salmonella is initially recognized in the chicken caecum by TLR receptors and this recognition is followed by induction of chemokines, cytokines and many effector genes. This results in infiltration of heterophils, macrophages, B- and T-lymphocytes and changes in total gene expression in the caecal lamina propria. The highest induction in expression is observed for matrix metalloproteinase 7 (MMP7). Expression of this gene is increased in the chicken caecum over 4000 fold during the first 10 days after the infection of newly hatched chickens. Additional highly inducible genes in the caecum following S. Enteritidis infection include immune responsive gene 1 (IRG1), serum amyloid A (SAA), extracellular fatty acid binding protein (ExFABP), serine protease inhibitor (SERPINB10), trappin 6-like (TRAP6), calprotectin (MRP126), mitochondrial ES1 protein homolog (ES1), interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), avidin (AVD) and transglutaminase 4 (TGM4). The induction of expression of these proteins exceeds a factor of 50. Similar induction rates are also observed for chemokines and cytokines such as IL1β, IL6, IL8, IL17, IL18, IL22, IFNγ, AH221 or iNOS. Once the infection is under control, which happens approx. 2 weeks after infection, expression of IgY and IgA increases to facilitate Salmonella elimination from the gut lumen. This review outlines the function of individual proteins expressed in chickens after infection with non-typhoid Salmonella serovars.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
France 1 1%
Belgium 1 1%
Unknown 72 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 23%
Student > Master 12 16%
Researcher 8 11%
Student > Doctoral Student 8 11%
Student > Bachelor 3 4%
Other 12 16%
Unknown 15 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 36%
Biochemistry, Genetics and Molecular Biology 8 11%
Veterinary Science and Veterinary Medicine 8 11%
Medicine and Dentistry 5 7%
Immunology and Microbiology 5 7%
Other 4 5%
Unknown 18 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#7,545,170
of 8,702,492 outputs
Outputs from Veterinary Research
#578
of 629 outputs
Outputs of similar age
#194,305
of 241,752 outputs
Outputs of similar age from Veterinary Research
#17
of 22 outputs
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So far Altmetric has tracked 629 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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