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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis
|
|---|---|
| Published in |
BMC Gastroenterology, December 2014
|
| DOI | 10.1186/s12876-014-0204-z |
| Pubmed ID | |
| Authors |
Vincenzo Cardinale, Guido Carpino, Raffaele Gentile, Chiara Napoletano, Hassan Rahimi, Antonio Franchitto, Rossella Semeraro, Marianna Nuti, Paolo Onori, Pasquale Bartolomeo Berloco, Massimo Rossi, Daniela Bosco, Roberto Brunelli, Alice Fraveto, Cristina Napoli, Alessia Torrice, Manuela Gatto, Rosanna Venere, Carlo Bastianelli, Camilla Aliberti, Filippo Maria Salvatori, Luciano Bresadola, Mario Bezzi, Adolfo Francesco Attili, Lola Reid, Eugenio Gaudio, Domenico Alvaro |
| Abstract |
BackgroundEfforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis.MethodsThe cells were immune-sorted from human fetal biliary tree by protocols in accordance with current good manufacturing practice (cGMP) and extensively characterized. Two patients with advanced cirrhosis (Child-Pugh C) have been submitted to the procedure and observed through a 12 months follow-up.ResultsThe resulting procedure was found absolutely safe. Immuno-suppressants were not required, and the patients did not display any adverse effects correlated with cell transplantation or suggestive of immunological complications. From a clinical point of view, both patients showed biochemical and clinical improvement during the 6 month follow-up (Table1), and the second patient maintained a stable improvement for 12 months.ConclusionThis report represents proof of the concept that the human fetal biliary tree stem cells are a suitable and large source for cell therapy of liver cirrhosis. The isolation procedure can be carried out under cGMP conditions and, finally, the infusion procedure is easy and safe for the patients. This represents the basis for forthcoming controlled clinical trials. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Russia | 1 | 20% |
| Italy | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 18% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Other | 10 | 20% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 45% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Agricultural and Biological Sciences | 3 | 6% |
| Chemical Engineering | 1 | 2% |
| Philosophy | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2016.
All research outputs
#13,661,887
of 23,577,654 outputs
Outputs from BMC Gastroenterology
#647
of 1,823 outputs
Outputs of similar age
#178,072
of 364,540 outputs
Outputs of similar age from BMC Gastroenterology
#8
of 18 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,823 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.