↓ Skip to main content

Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer

Overview of attention for article published in Breast Cancer Research, November 2014
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
7 X users
facebook
1 Facebook page

Citations

dimensions_citation
204 Dimensions

Readers on

mendeley
229 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer
Published in
Breast Cancer Research, November 2014
DOI 10.1186/s13058-014-0488-5
Pubmed ID
Authors

Elena García-Martínez, Ginés Luengo Gil, Asunción Chaves Benito, Enrique González-Billalabeitia, María Angeles Vicente Conesa, Teresa García García, Elisa García-Garre, Vicente Vicente, Francisco Ayala de la Peña

Abstract

IntroductionTumor microenvironment immunity is associated with breast cancer outcome. A high lymphocytic infiltration has been associated with response to neoadjuvant chemotherapy, but the contribution to response and prognosis of immune cell subpopulations profiles in both pre-treated and post-treatment residual tumor is still unclear.MethodsWe analyzed pre- and post-treatment tumor-infiltrating immune cells (CD3, CD4, CD8, CD20, CD68, Foxp3) by immunohistochemistry in a series of 121 breast cancer patients homogeneously treated with neoadjuvant chemotherapy. Immune cell profiles were analyzed and correlated with response and survival.ResultsWe identified three tumor-infiltrating immune cell profiles, which were able to predict pathological complete response (pCR) to neoadjuvant chemotherapy (cluster B: 58%, versus clusters A and C: 7%). A higher infiltration by CD4 lymphocytes was the main factor explaining the occurrence of pCR, and this association was validated in six public genomic datasets. A higher chemotherapy effect on lymphocytic infiltration, including an inversion of CD4/CD8 ratio, was associated with pCR and with better prognosis. Analysis of the immune infiltrate in post-chemotherapy residual tumor identified a profile (cluster Y), mainly characterized by high CD3 and CD68 infiltration, with a worse disease free survival.ConclusionsBreast cancer immune cell subpopulation profiles, determined by immunohistochemistry-based computerized analysis, identify groups of patients characterized by high response (in the pre-treatment setting) and poor prognosis (in the post-treatment setting). Further understanding of the mechanisms underlying the distribution of immune cells and their changes after chemotherapy may contribute to the development of new immune-targeted therapies for breast cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Chile 1 <1%
Norway 1 <1%
Italy 1 <1%
Austria 1 <1%
Australia 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Unknown 221 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 44 19%
Student > Ph. D. Student 41 18%
Student > Master 29 13%
Student > Doctoral Student 18 8%
Student > Bachelor 15 7%
Other 48 21%
Unknown 34 15%
Readers by discipline Count As %
Medicine and Dentistry 70 31%
Biochemistry, Genetics and Molecular Biology 33 14%
Agricultural and Biological Sciences 32 14%
Immunology and Microbiology 10 4%
Computer Science 6 3%
Other 30 13%
Unknown 48 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2020.
All research outputs
#7,264,355
of 25,374,917 outputs
Outputs from Breast Cancer Research
#839
of 2,053 outputs
Outputs of similar age
#93,461
of 369,658 outputs
Outputs of similar age from Breast Cancer Research
#15
of 50 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,658 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.