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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, December 2014
|
| DOI | 10.1186/s13075-014-0500-6 |
| Pubmed ID | |
| Authors |
Irene Arroyo-Villa, María-Belén Bautista-Caro, Alejandro Balsa, Pilar Aguado-Acín, María-Gema Bonilla-Hernán, Chamaida Plasencia, Alejandro Villalba, Laura Nuño, Amaya Puig-Kröger, Emilio Martín-Mola, María-Eugenia Miranda-Carús |
| Abstract |
IntroductionCirculating CD4 T cells expressing CXCR5, ICOS and/or PD-1 are counterparts of follicular helper T cells (Tfh). There are three subpopulations of circulating Tfh (cTfh): CXCR5¿+¿CXCR3¿+¿CCR6- (Tfh-Th1), CXCR5¿+¿CXCR3-CCR6- (Tfh-Th2) and CXCR5¿+¿CXCR3-CCR6+ (Tfh-Th17). Our objective was to study the B cell helping capacity of cTfh subsets, and examine their frequency in Rheumatoid Arthritis (RA) patients, together with the frequency of circulating plasmablasts (CD19¿+¿CD20-CD38high).MethodsPeripheral blood was drawn from RA patients with active disease (RA-a, DAS28¿>¿2.6) (n¿=¿17), RA in remission (RA-r, DAS28¿<¿2.6) (n¿=¿17) and healthy controls (HC) (n¿=¿34). cTfh and plasmablast frequencies were determined by flow cytometry. Cocultures of sorted CD4¿+¿CXCR5+ T cell subpopulations were established with autologous CD19¿+¿CD27- naïve B cells of HC, and concentrations of IgG, A and M were measured in supernatants.ResultsIsolated Tfh-Th2 and Tfh-Th17 but not Tfh-Th1 cells, induced naïve B cells to secrete IgG and IgA. The frequency of CXCR5+ cells gated for CD4+ T cells was not different among HC, RA-a and RA-r. In contrast, both RA-a and RA-r patients demonstrated an increased frequency of CD4¿+¿CXCR5¿+¿ICOS+ T cells and augmented (%Tfh-Th2¿+¿%Tfh-Th17)/%Tfh-Th1 ratio as compared with HC. In addition, RA-a but not RA-r patients, showed an increased frequency of circulating plasmablasts.ConclusionBoth RA-a and RA-r patients demonstrate an increased frequency of cTfh and overrepresentation of cTfh subsets bearing a B cell helper phenotype, suggesting that altered germinal center dynamics play a role in RA pathogenesis. In contrast, only RA-a patients show an increased proportion of circulating plasmablasts. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Mexico | 1 | 2% |
| Portugal | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 24% |
| Researcher | 11 | 19% |
| Student > Bachelor | 8 | 14% |
| Student > Master | 8 | 14% |
| Professor | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 6 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 14 | 24% |
| Medicine and Dentistry | 14 | 24% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Agricultural and Biological Sciences | 8 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Other | 3 | 5% |
| Unknown | 7 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2020.
All research outputs
#7,355,930
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#1,510
of 3,381 outputs
Outputs of similar age
#93,789
of 367,041 outputs
Outputs of similar age from Arthritis Research & Therapy
#25
of 55 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,041 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.