Title |
Gene expression of tendon markers in mesenchymal stromal cells derived from different sources
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Published in |
BMC Research Notes, November 2014
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DOI | 10.1186/1756-0500-7-826 |
Pubmed ID | |
Authors |
Janina Burk, Claudia Gittel, Sandra Heller, Bastian Pfeiffer, Felicitas Paebst, Annette B Ahrberg, Walter Brehm |
Abstract |
Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the MSC source on their properties relevant to tendon regeneration.The aim of this study was to assess and compare the expression of tendon extracellular matrix proteins and tendon differentiation markers in MSC derived from different sources as well as in native tendon tissue. MSC isolated from equine bone marrow, adipose tissue, umbilical cord tissue, umbilical cord blood and tendon tissue were characterized and then subjected to mRNA analysis by real-time polymerase chain reaction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 40% |
Germany | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 23% |
Student > Ph. D. Student | 10 | 23% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Researcher | 3 | 7% |
Other | 5 | 12% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 21% |
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Veterinary Science and Veterinary Medicine | 6 | 14% |
Agricultural and Biological Sciences | 6 | 14% |
Engineering | 2 | 5% |
Other | 4 | 9% |
Unknown | 8 | 19% |