Title |
Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis
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Published in |
BMC Musculoskeletal Disorders, December 2014
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DOI | 10.1186/1471-2474-15-414 |
Pubmed ID | |
Authors |
Melanie Gruner, Anja Moncsek, Stefan Rödiger, Dagmar Kühnhardt, Eugen Feist, Ralf Stohwasser |
Abstract |
PA28γ (also known as Ki, REG gamma, PMSE3), a member of the ubiquitin-and ATP-independent proteasome activator family 11S, has been proved to show proteasome-dependent and -independent effects on several proteins including tumor suppressor p53, cyclin-dependent kinase inhibitor p21 and steroid receptor co-activator 3 (SCR-3). Interestingly, PA28γ is overexpressed in pathological tissue of various cancers affecting e. g. breast, bowl and thyroids. Furthermore, anti-PA28γ autoantibodies have been linked to several autoimmune disorders. The aim of this study was to develop and evaluate a novel and sensitive PA28γ sandwich ELISA for the quantification of PA28γ serum levels in patients with cancer and autoimmune diseases for diagnostic and prognostic purposes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 18% |
Researcher | 5 | 13% |
Student > Master | 5 | 13% |
Student > Bachelor | 5 | 13% |
Student > Doctoral Student | 3 | 8% |
Other | 10 | 25% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 43% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Agricultural and Biological Sciences | 4 | 10% |
Psychology | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 3 | 8% |
Unknown | 7 | 18% |