Title |
Sex differences in mood disorders: perspectives from humans and rodent models
|
---|---|
Published in |
Biology of Sex Differences, December 2014
|
DOI | 10.1186/s13293-014-0017-3 |
Pubmed ID | |
Authors |
Marianne L Seney, Etienne Sibille |
Abstract |
Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 18% |
United States | 2 | 12% |
Mexico | 2 | 12% |
Indonesia | 1 | 6% |
Japan | 1 | 6% |
Unknown | 8 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 94% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
United States | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 167 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 16% |
Student > Ph. D. Student | 26 | 15% |
Student > Master | 24 | 14% |
Researcher | 19 | 11% |
Professor > Associate Professor | 10 | 6% |
Other | 30 | 18% |
Unknown | 34 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 36 | 21% |
Psychology | 25 | 15% |
Agricultural and Biological Sciences | 16 | 9% |
Medicine and Dentistry | 14 | 8% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Other | 17 | 10% |
Unknown | 49 | 29% |